PDF(Pubmed)
Abstract：
UNASSIGNED: To identify the relationship between thyroid autoimmunity and antinuclear antibody (ANA) prevalence in Chinese pregnant women.
UNASSIGNED: The study involved 1923 first-trimester women who were measured for thyroid stimulating hormone (TSH) level, thyroid autoantibodies (thyroperoxidase antibody [TPOAb] and thyroglobulin antibody [TgAb]) and ANA titer. Social demographic data were collected through standardized questionnaires.
UNASSIGNED: In this study, 23.3% of pregnant women tested positive for TPOAb and 9.9% tested positive for TgAb. Women with a positive ANA were more likely to be TPOAb-positive or TgAb-positive than women with a negative ANA (adjusted odds ratio [AOR] 1.96, 95% confidence interval [CI] 1.47-2.62 for TPOAb [+]; AOR 3.12, 95% CI 2.18-4.48 for TgAb[+]). In addition, ANA titers were closely associated with thyroid autoimmunity. Women with an ANA titer of >1:320 had a significant higher risk of being TPOAb positive or TgAb positive (AOR 4.49, 95% CI 1.48-13.66 for TPOAb [+]; AOR 5.51, 95% CI 1.65-18.49 for TgAb [+]). The higher the ANA titer, the greater the risk of developing thyroid autoimmunity, especially for those with a high ANA titer.
UNASSIGNED: ANA positivity is strongly correlated with thyroid autoimmunity. Further study is warranted to clarify the causal relationship between thyroid autoimmunity and ANA in pregnant women.This research is essential to evaluate and predict the risk of co-existing autoimmune disorders,leading to improved care for pregnancy and neonatal health.
UNASSIGNED: The study involved 1923 first-trimester women who were measured for thyroid stimulating hormone (TSH) level, thyroid autoantibodies (thyroperoxidase antibody [TPOAb] and thyroglobulin antibody [TgAb]) and ANA titer. Social demographic data were collected through standardized questionnaires.
UNASSIGNED: In this study, 23.3% of pregnant women tested positive for TPOAb and 9.9% tested positive for TgAb. Women with a positive ANA were more likely to be TPOAb-positive or TgAb-positive than women with a negative ANA (adjusted odds ratio [AOR] 1.96, 95% confidence interval [CI] 1.47-2.62 for TPOAb [+]; AOR 3.12, 95% CI 2.18-4.48 for TgAb[+]). In addition, ANA titers were closely associated with thyroid autoimmunity. Women with an ANA titer of >1:320 had a significant higher risk of being TPOAb positive or TgAb positive (AOR 4.49, 95% CI 1.48-13.66 for TPOAb [+]; AOR 5.51, 95% CI 1.65-18.49 for TgAb [+]). The higher the ANA titer, the greater the risk of developing thyroid autoimmunity, especially for those with a high ANA titer.
UNASSIGNED: ANA positivity is strongly correlated with thyroid autoimmunity. Further study is warranted to clarify the causal relationship between thyroid autoimmunity and ANA in pregnant women.This research is essential to evaluate and predict the risk of co-existing autoimmune disorders,leading to improved care for pregnancy and neonatal health.
摘要：
■确定中国孕妇甲状腺自身免疫与抗核抗体（ANA）患病率之间的关系。
■这项研究涉及1923年头三个月的妇女，她们测量了促甲状腺激素（TSH）水平，甲状腺自身抗体（甲状腺过氧化物酶抗体[TPOAb]和甲状腺球蛋白抗体[TgAb]）和ANA滴度。社会人口统计数据是通过标准化问卷收集的。
■在这项研究中，23.3%的孕妇TPOAb检测呈阳性，9.9%的孕妇TgAb检测呈阳性。ANA阳性的女性比ANA阴性的女性更可能是TPOAb阳性或TgAb阳性（TPOAb[+]的调整比值比[AOR]1.96，95%置信区间[CI]1.47-2.62；TgAb[+]的AOR3.12，95%CI2.18-4.48）。此外,ANA滴度与甲状腺自身免疫密切相关。ANA滴度>1:320的女性TPOAb阳性或TgAb阳性的风险显著较高(TPOAb[+]AOR4.49,95%CI1.48-13.66;TgAb[+]AOR5.51,95%CI1.65-18.49)。ANA滴度越高,发生甲状腺自身免疫的风险越大，特别是对于那些具有高ANA滴度。
■ANA阳性与甲状腺自身免疫密切相关。需要进一步研究以阐明孕妇甲状腺自身免疫与ANA之间的因果关系。这项研究对于评估和预测共存的自身免疫性疾病的风险至关重要，改善对怀孕和新生儿健康的护理。
■这项研究涉及1923年头三个月的妇女，她们测量了促甲状腺激素（TSH）水平，甲状腺自身抗体（甲状腺过氧化物酶抗体[TPOAb]和甲状腺球蛋白抗体[TgAb]）和ANA滴度。社会人口统计数据是通过标准化问卷收集的。
■在这项研究中，23.3%的孕妇TPOAb检测呈阳性，9.9%的孕妇TgAb检测呈阳性。ANA阳性的女性比ANA阴性的女性更可能是TPOAb阳性或TgAb阳性（TPOAb[+]的调整比值比[AOR]1.96，95%置信区间[CI]1.47-2.62；TgAb[+]的AOR3.12，95%CI2.18-4.48）。此外,ANA滴度与甲状腺自身免疫密切相关。ANA滴度>1:320的女性TPOAb阳性或TgAb阳性的风险显著较高(TPOAb[+]AOR4.49,95%CI1.48-13.66;TgAb[+]AOR5.51,95%CI1.65-18.49)。ANA滴度越高,发生甲状腺自身免疫的风险越大，特别是对于那些具有高ANA滴度。
■ANA阳性与甲状腺自身免疫密切相关。需要进一步研究以阐明孕妇甲状腺自身免疫与ANA之间的因果关系。这项研究对于评估和预测共存的自身免疫性疾病的风险至关重要，改善对怀孕和新生儿健康的护理。
