PDF(Pubmed)
Abstract：
Inflammatory bowel disease (IBD), including Crohn\'s disease and ulcerative colitis, showed a wide spectrum of intestinal and extra-intestinal manifestations, which rendered the patients physically inactive and impaired their quality of life. It has been found that physical activity is a non-pharmacological intervention that improves the quality of life for those patients. Irisin is one member of the myokines secreted by muscle contraction during exercise and could be used as an anti-inflammatory biomarker in assessing the physical activity of IBD patients. In addition, experimental studies showed that exogenous irisin significantly decreased the inflammatory markers and the histological changes of the intestinal mucosa observed in experimental colitis. Furthermore, irisin produces changes in the diversity of the microbiota. Therefore, endogenous or exogenous irisin, via its anti-inflammatory effects, will improve the health of IBD patients and will limit the barriers to physical activity in patients with IBD.
摘要：
炎症性肠病(IBD),包括克罗恩病和溃疡性结肠炎，表现出广泛的肠道和肠道外表现，这使得患者身体不活跃，生活质量受损。已经发现,身体活动是改善那些患者的生活质量的非药物干预。Irisin是运动过程中肌肉收缩分泌的肌细胞因子之一，可用作评估IBD患者身体活动的抗炎生物标志物。此外,实验研究表明，外源性irisin可显著降低实验性结肠炎患者的炎症指标和肠黏膜组织学变化。此外，irisin会改变微生物群的多样性。因此,内源性或外源性irisin，通过它的抗炎作用，将改善IBD患者的健康状况，并限制IBD患者的体育锻炼障碍。
