PDF(Pubmed)
Abstract：
Nodal regions, areas of intensive contact between Schwann cells and axons, may be exceptionally vulnerable to diabetes-induced changes because they are exposed to and impacted by the metabolic implications of diabetes. Insulin receptors, glucose transporters, Na+ and K+ channels, and mitochondria are abundant in nodes, all of which have been linked to the development and progression of Diabetic Peripheral Neuropathy (DPN) and Type 1 Diabetes Mellitus (T1DM)-associated cognitive impairment. Our study aimed to evaluate if the administration of Nigella sativa (NS) and Cassia angustifolia (CA) prevented diabetes-associated nervous system deficits in hyperglycemic mice. We developed T1DM mice through Streptozotocin (STZ) injections and validated the elevations in blood glucose levels. NS and CA were administered immediately upon the induction of diabetes. Behavioral analysis, histopathological evaluations, and assessment of molecular biomarkers (NR2A, MPZ, NfL) were performed to assess neuropathy and cognitive impairment. Improvements in memory, myelin loss, and the expression of synaptic proteins, even with the retention of hyperglycemia, were evident in the mice who were given a dose of herbal products upon the detection of hyperglycemia. NS was more beneficial in preventing memory impairments, demyelination, and synaptic dysfunction. The findings indicate that including these herbs in the diets of diabetic as well as pre-diabetic patients can reduce complications associated with T1DM, notably diabetic peripheral neuropathy and cognitive deficits associated with T1DM.
摘要：
节点区域,施万细胞和轴突之间密集接触的区域，可能特别容易受到糖尿病引起的变化，因为它们暴露于糖尿病的代谢影响并受其影响。胰岛素受体,葡萄糖转运蛋白,Na+和K+通道,线粒体在节点中丰富，所有这些都与糖尿病周围神经病变（DPN）和1型糖尿病（T1DM）相关的认知障碍的发生和发展有关。我们的研究旨在评估在高血糖小鼠中施用Nigellasativa（NS）和决明子（CA）是否可以预防与糖尿病相关的神经系统缺陷。我们通过链脲佐菌素（STZ）注射开发了T1DM小鼠，并验证了血糖水平的升高。在诱导糖尿病后立即施用NS和CA。行为分析,组织病理学评估,和分子生物标志物的评估(NR2A，MPZ,进行NfL）以评估神经病变和认知障碍。内存的改进，髓鞘丢失,和突触蛋白的表达，即使保持高血糖，在检测到高血糖后给予一定剂量的草药产品的小鼠中很明显。NS在预防记忆障碍方面更有益，脱髓鞘,和突触功能障碍.研究结果表明，在糖尿病和糖尿病前期患者的饮食中加入这些草药可以减少与T1DM相关的并发症。特别是与T1DM相关的糖尿病周围神经病变和认知障碍。
