Abstract：
UNASSIGNED: Paraphenylenediamine is the main component in many commercial hair dyes, and can produce severe local and systemic toxicity reactions after acute ingestion or dermal absorption. The aim of this study was to assess the factors contributing to morbidity and mortality in cases of acute paraphenylenediamine poisoning, with a focus on evaluating the resultant hepatic and cardiac toxicity.
UNASSIGNED: This observational study was conducted on patients with acute paraphenylenediamine poisoning presenting to Sohag University Hospitals, and included a retrospective part from February 2021 to January 2022 and a prospective part from February 2022 to July 2022. Clinical data were extracted and receiver operating characteristic curves created to identify prognostic markers.
UNASSIGNED: Among 50 eligible patients 39 (78 percent) recovered, and 11 (22 percent) died or had permanent complications. Angioedema and anuria were the most frequent features in complicated cases. By receiver operating characteristic analysis, either an increase in aspartate aminotransferase activity greater than 644 IU/L or alanine aminotransferase activity greater than 798 IU/L, a time delay to presentation of greater than 4.5 hours, and a pH of less than 7.32 were associated with a significant increase in morbidity and mortality. While cardiac enzyme activities, and concentrations of blood urea nitrogen and creatinine increased in most cases, they were not associated with mortality.
UNASSIGNED: Management of patients with paraphenylenediamine poisoning is mainly supportive, as there is no specific antidote. Respiratory failure and kidney failure are the most life threatening complications. Hepatoxicity and cardiotoxicity also occur. The ability to predict the events can help guide patient disposition and care.
UNASSIGNED: Elevated liver enzyme activities, increased time delay to admission, decreased pH, and the presence of angioedema and anuria can be used as predictors of morbidity and mortality in patients with acute paraphenylenediamine poisoning.
UNASSIGNED: This observational study was conducted on patients with acute paraphenylenediamine poisoning presenting to Sohag University Hospitals, and included a retrospective part from February 2021 to January 2022 and a prospective part from February 2022 to July 2022. Clinical data were extracted and receiver operating characteristic curves created to identify prognostic markers.
UNASSIGNED: Among 50 eligible patients 39 (78 percent) recovered, and 11 (22 percent) died or had permanent complications. Angioedema and anuria were the most frequent features in complicated cases. By receiver operating characteristic analysis, either an increase in aspartate aminotransferase activity greater than 644 IU/L or alanine aminotransferase activity greater than 798 IU/L, a time delay to presentation of greater than 4.5 hours, and a pH of less than 7.32 were associated with a significant increase in morbidity and mortality. While cardiac enzyme activities, and concentrations of blood urea nitrogen and creatinine increased in most cases, they were not associated with mortality.
UNASSIGNED: Management of patients with paraphenylenediamine poisoning is mainly supportive, as there is no specific antidote. Respiratory failure and kidney failure are the most life threatening complications. Hepatoxicity and cardiotoxicity also occur. The ability to predict the events can help guide patient disposition and care.
UNASSIGNED: Elevated liver enzyme activities, increased time delay to admission, decreased pH, and the presence of angioedema and anuria can be used as predictors of morbidity and mortality in patients with acute paraphenylenediamine poisoning.
摘要：
■对苯二胺是许多商业染发剂中的主要成分，急性摄入或皮肤吸收后可产生严重的局部和全身毒性反应。这项研究的目的是评估导致急性对苯二胺中毒病例的发病率和死亡率的因素。重点评估由此产生的肝和心脏毒性。
■这项观察性研究是针对在Sohag大学医院就诊的急性对亚苯基二胺中毒患者进行的，并包括2021年2月至2022年1月的回顾性部分和2022年2月至2022年7月的预期部分。提取临床数据并创建接受者操作特征曲线以鉴定预后标志物。
■在50名符合条件的患者中，有39名（78％）康复，11人(22%)死亡或有永久性并发症。在复杂病例中，血管性水肿和无尿是最常见的特征。通过接收机工作特性分析,天冬氨酸转氨酶活性的增加大于644IU/L或丙氨酸转氨酶活性大于798IU/L，提交的时间延迟超过4.5小时，pH值小于7.32与发病率和死亡率的显著增加相关.虽然心脏酶活性，在大多数情况下，血尿素氮和肌酐的浓度增加，它们与死亡率无关.
■对亚苯基二胺中毒患者的处理主要是支持性的，因为没有特定的解毒剂。呼吸衰竭和肾衰竭是最危及生命的并发症。也发生肝毒性和心脏毒性。预测事件的能力可以帮助指导患者的处置和护理。
■肝酶活性升高，增加了入院的时间延迟，pH值降低,血管性水肿和无尿的存在可以作为急性对苯二胺中毒患者发病率和死亡率的预测因子。
■这项观察性研究是针对在Sohag大学医院就诊的急性对亚苯基二胺中毒患者进行的，并包括2021年2月至2022年1月的回顾性部分和2022年2月至2022年7月的预期部分。提取临床数据并创建接受者操作特征曲线以鉴定预后标志物。
■在50名符合条件的患者中，有39名（78％）康复，11人(22%)死亡或有永久性并发症。在复杂病例中，血管性水肿和无尿是最常见的特征。通过接收机工作特性分析,天冬氨酸转氨酶活性的增加大于644IU/L或丙氨酸转氨酶活性大于798IU/L，提交的时间延迟超过4.5小时，pH值小于7.32与发病率和死亡率的显著增加相关.虽然心脏酶活性，在大多数情况下，血尿素氮和肌酐的浓度增加，它们与死亡率无关.
■对亚苯基二胺中毒患者的处理主要是支持性的，因为没有特定的解毒剂。呼吸衰竭和肾衰竭是最危及生命的并发症。也发生肝毒性和心脏毒性。预测事件的能力可以帮助指导患者的处置和护理。
■肝酶活性升高，增加了入院的时间延迟，pH值降低,血管性水肿和无尿的存在可以作为急性对苯二胺中毒患者发病率和死亡率的预测因子。
