Abstract：
Persistent inflammation in chronic HIV infection may affect immune responses against SARS-CoV-2 infection. Plasma levels of multiple proinflammatory cytokines during acute SARS-CoV-2 infection were assessed in people with HIV (PWH) with effective cART. There were no significant differences in any of the tested cytokines between COVID-19 severity in PWH, while most of them were significantly higher in individuals with severe disease in HIV-uninfected individuals, suggesting that excess cytokines release by hyper-inflammatory responses does not occur in severe COVID-19 with HIV infection. The strong associations between the cytokines observed in HIV-uninfected individuals, especially between IFN-α/TNF-α and other cytokines, were lost in PWH. The steady state plasma levels of IP-10, ICAM-1, and CD62E were significantly higher in PWH, indicating that PWH are in an enhanced inflammatory state. Loss of the several inter-cytokine correlations were observed in in vitro LPS stimuli-driven cytokines production in PWH. These data suggest that inflammatory responses during SARS-CoV-2 infection in PWH are distinct from those in HIV-uninfected individuals, partially due to the underlying inflammatory state and/or impairment of innate immune cells.
摘要：
慢性HIV感染中的持续炎症可能会影响针对SARS-CoV-2感染的免疫应答。在具有有效cART的HIV感染者（PWH）中评估了急性SARS-CoV-2感染期间多种促炎细胞因子的血浆水平。在PWH中，任何测试的细胞因子在COVID-19严重程度之间没有显着差异，尽管在未感染艾滋病毒的人中，大多数人在患有严重疾病的人中明显更高，这表明，过度炎症反应释放的过量细胞因子不会发生在严重的COVID-19合并HIV感染中。在未感染HIV的个体中观察到的细胞因子之间的强烈关联，特别是在IFN-α/TNF-α和其他细胞因子之间，在PWH中迷路了。PWH中IP-10、ICAM-1和CD62E的稳态血浆水平显著升高,表明PWH处于增强的炎症状态。在PWH中体外LPS刺激驱动的细胞因子产生中观察到几种细胞因子间相关性的丧失。这些数据表明，PWH中SARS-CoV-2感染期间的炎症反应与未感染HIV的个体不同，部分是由于潜在的炎症状态和/或先天免疫细胞的损伤。
