%0 Journal Article
%T Characterization of proinflammatory cytokines profile during acute SARS-CoV-2 infection in people with human immunodeficiency virus.
%A Anzurez A
%A Runtuwene L
%A Dang TTT
%A Nakayama-Hosoya K
%A Koga M
%A Yoshimura Y
%A Sasaki H
%A Miyata N
%A Miyazaki K
%A Takahashi Y
%A Suzuki T
%A Yotsuyanagi H
%A Tachikawa N
%A Matano T
%A Kawana-Tachikawa A
%J Jpn J Infect Dis
%V 0
%N 0
%D 2024 Jun 28
%M 38945856
%F 2.541
%R 10.7883/yoken.JJID.2024.184
%X Persistent inflammation in chronic HIV infection may affect immune responses against SARS-CoV-2 infection. Plasma levels of multiple proinflammatory cytokines during acute SARS-CoV-2 infection were assessed in people with HIV (PWH) with effective cART. There were no significant differences in any of the tested cytokines between COVID-19 severity in PWH, while most of them were significantly higher in individuals with severe disease in HIV-uninfected individuals, suggesting that excess cytokines release by hyper-inflammatory responses does not occur in severe COVID-19 with HIV infection. The strong associations between the cytokines observed in HIV-uninfected individuals, especially between IFN-α/TNF-α and other cytokines, were lost in PWH. The steady state plasma levels of IP-10, ICAM-1, and CD62E were significantly higher in PWH, indicating that PWH are in an enhanced inflammatory state. Loss of the several inter-cytokine correlations were observed in in vitro LPS stimuli-driven cytokines production in PWH. These data suggest that inflammatory responses during SARS-CoV-2 infection in PWH are distinct from those in HIV-uninfected individuals, partially due to the underlying inflammatory state and/or impairment of innate immune cells.