{Reference Type}: Journal Article
{Title}: Characterization of proinflammatory cytokines profile during acute SARS-CoV-2 infection in people with human immunodeficiency virus.
{Author}: Anzurez A;Runtuwene L;Dang TTT;Nakayama-Hosoya K;Koga M;Yoshimura Y;Sasaki H;Miyata N;Miyazaki K;Takahashi Y;Suzuki T;Yotsuyanagi H;Tachikawa N;Matano T;Kawana-Tachikawa A;
{Journal}: Jpn J Infect Dis
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 28
{Factor}: 2.541
{DOI}: 10.7883/yoken.JJID.2024.184
{Abstract}: Persistent inflammation in chronic HIV infection may affect immune responses against SARS-CoV-2 infection. Plasma levels of multiple proinflammatory cytokines during acute SARS-CoV-2 infection were assessed in people with HIV (PWH) with effective cART. There were no significant differences in any of the tested cytokines between COVID-19 severity in PWH, while most of them were significantly higher in individuals with severe disease in HIV-uninfected individuals, suggesting that excess cytokines release by hyper-inflammatory responses does not occur in severe COVID-19 with HIV infection. The strong associations between the cytokines observed in HIV-uninfected individuals, especially between IFN-α/TNF-α and other cytokines, were lost in PWH. The steady state plasma levels of IP-10, ICAM-1, and CD62E were significantly higher in PWH, indicating that PWH are in an enhanced inflammatory state. Loss of the several inter-cytokine correlations were observed in in vitro LPS stimuli-driven cytokines production in PWH. These data suggest that inflammatory responses during SARS-CoV-2 infection in PWH are distinct from those in HIV-uninfected individuals, partially due to the underlying inflammatory state and/or impairment of innate immune cells.