关键词: CRISPR Orofacial Regenerative Stem cells Therapeutic Urine

Mesh : Humans Stem Cells / cytology Regenerative Medicine / methods Animals Urine / cytology Cell Differentiation Plastic Surgery Procedures / methods Regeneration / physiology Stem Cell Transplantation / methods Tissue Engineering / methods Mesenchymal Stem Cells / cytology

来  源:   DOI:10.1016/j.biopha.2024.117005

Abstract:
Urine-derived stem cells (USCs) have gained the attention of researchers in the biomedical field in the past few years . Regarding the several varieties of cells that have been used for this purpose, USCs have demonstrated mesenchymal stem cell-like properties, such as differentiation and immunomodulation. Furthermore, they could be differentiated into several lineages. This is very interesting for regenerative techniques based on cell therapy. This review will embark on describing their separation, and profiling. We will specifically describe the USCs characteristics, in addition to their differentiation potential. Then, we will introduce and explore the primary uses of USCs. These involve thier utilization as a platform to produce stem cells, however, we shall concentrate on the utilization of USCs for therapeutic, and regenerative orofacial applications, providing an in-depth evaluation of this purpose. The final portion will address the limitations and challenges of their implementation in regenerative dentistry.
摘要:
在过去的几年中,尿液来源的干细胞(USCs)获得了生物医学领域研究人员的关注。关于已用于此目的的几种细胞,USC已经证明了间充质干细胞样特性,如分化和免疫调节。此外,它们可以分为几个谱系。这对于基于细胞疗法的再生技术非常有趣。这篇评论将开始描述他们的分离,和剖析。我们将具体描述USC的特征,除了他们的差异化潜力。然后,我们将介绍和探讨USC的主要用途。这些涉及到作为生产干细胞的平台的利用,然而,我们将专注于利用USC进行治疗,和再生口腔应用,对此目的进行了深入的评估。最后一部分将解决其在再生牙科实施的局限性和挑战。
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