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Abstract：
OBJECTIVE: This study aimed to examine prospective associations of different intensity levels and types of physical activity (PA) in early pregnancy with premature rupture of membranes (PROM) among Chinese pregnant women.
METHODS: A total of 6284 pregnant women were included from the Tongji-Shuangliu Birth Cohort. Household/caregiving, occupational, sports/exercise and transportation activities during early pregnancy were investigated by the pregnancy physical activity questionnaire (PPAQ), and the diagnosis of PROM was ascertained during the whole pregnancy. Multivariate logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence interval (CI) for the associations between PA and PROM.
RESULTS: Among the 6284 pregnant women, 1246 were identified to have PROM (19.8%). Women undertaking the highest level (3 third tertile) of PA during pregnancy appeared to have a lower risk of PROM [OR = 0.68, 95%CI 0.58-0.80) when compared to those at the lowest tertile of PA. Similarly, women with increased levels of light intensity activity, moderate-vigorous intensive, household/caregiving activity and meeting exercise guidelines during pregnancy were associated with reduced risks of PROM (OR = 0.69, 95% CI 0.59-0.81, OR = 0.70, 95% CI 0.60-0.82, OR = 0.62, 95% CI 0.53-0.73 and OR = 0.82, 95% CI 0.70-0.97, respectively).
CONCLUSIONS: High levels of PA of different intensities and PA of household/caregiving activities and meeting exercise guidelines during the first trimester were associated with a lower incidence of PROM.
BACKGROUND: The data of human participants in this study were conducted in accordance with the Helsinki Declaration. This study has been approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ([2017] No. S225). All participants provided written informed consent prior to enrollment. A statement to confirm that all methods were carried out in accordance with relevant guidelines and regulations.
METHODS: A total of 6284 pregnant women were included from the Tongji-Shuangliu Birth Cohort. Household/caregiving, occupational, sports/exercise and transportation activities during early pregnancy were investigated by the pregnancy physical activity questionnaire (PPAQ), and the diagnosis of PROM was ascertained during the whole pregnancy. Multivariate logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence interval (CI) for the associations between PA and PROM.
RESULTS: Among the 6284 pregnant women, 1246 were identified to have PROM (19.8%). Women undertaking the highest level (3 third tertile) of PA during pregnancy appeared to have a lower risk of PROM [OR = 0.68, 95%CI 0.58-0.80) when compared to those at the lowest tertile of PA. Similarly, women with increased levels of light intensity activity, moderate-vigorous intensive, household/caregiving activity and meeting exercise guidelines during pregnancy were associated with reduced risks of PROM (OR = 0.69, 95% CI 0.59-0.81, OR = 0.70, 95% CI 0.60-0.82, OR = 0.62, 95% CI 0.53-0.73 and OR = 0.82, 95% CI 0.70-0.97, respectively).
CONCLUSIONS: High levels of PA of different intensities and PA of household/caregiving activities and meeting exercise guidelines during the first trimester were associated with a lower incidence of PROM.
BACKGROUND: The data of human participants in this study were conducted in accordance with the Helsinki Declaration. This study has been approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ([2017] No. S225). All participants provided written informed consent prior to enrollment. A statement to confirm that all methods were carried out in accordance with relevant guidelines and regulations.
摘要：
目的：本研究旨在探讨中国孕妇妊娠早期不同强度和类型的体力活动（PA）与胎膜早破（PROM）的前瞻性关联。
方法：从同济双流出生队列中纳入6284名孕妇。家庭/护理，职业,通过妊娠体力活动问卷（PPAQ）调查妊娠早期的运动/运动和交通活动，并在整个妊娠期间确定了胎膜早破的诊断。使用多变量逻辑回归模型来估计PA和PROM之间关联的比值比（OR）和95％置信区间（CI）。
结果：在6284名孕妇中，1246例被鉴定为有PROM(19.8%)。与PA最低三分位数的妇女相比，怀孕期间PA最高水平（三分位数）的妇女发生PROM的风险较低[OR=0.68，95CI0.58-0.80）。同样，光强度活动水平增加的女性，中等强度，孕期家庭/护理活动和符合运动指南与胎膜早破风险降低相关(分别为OR=0.69,95%CI0.59-0.81,OR=0.70,95%CI0.60-0.82,OR=0.62,95%CI0.53-0.73和OR=0.82,95%CI0.70-0.97).
结论：孕早期不同强度的PA水平和家庭/看护活动和满足运动指南的PA水平高与胎膜早破发生率较低相关。
背景：本研究中人类参与者的数据是根据《赫尔辛基宣言》进行的。本研究已获同济医学院伦理委员会批准,华中科技大学,武汉,中国（[2017]编号S225).所有参与者在登记前提供书面知情同意书。声明确认所有方法均按照相关准则和规定进行。
方法：从同济双流出生队列中纳入6284名孕妇。家庭/护理，职业,通过妊娠体力活动问卷（PPAQ）调查妊娠早期的运动/运动和交通活动，并在整个妊娠期间确定了胎膜早破的诊断。使用多变量逻辑回归模型来估计PA和PROM之间关联的比值比（OR）和95％置信区间（CI）。
结果：在6284名孕妇中，1246例被鉴定为有PROM(19.8%)。与PA最低三分位数的妇女相比，怀孕期间PA最高水平（三分位数）的妇女发生PROM的风险较低[OR=0.68，95CI0.58-0.80）。同样，光强度活动水平增加的女性，中等强度，孕期家庭/护理活动和符合运动指南与胎膜早破风险降低相关(分别为OR=0.69,95%CI0.59-0.81,OR=0.70,95%CI0.60-0.82,OR=0.62,95%CI0.53-0.73和OR=0.82,95%CI0.70-0.97).
结论：孕早期不同强度的PA水平和家庭/看护活动和满足运动指南的PA水平高与胎膜早破发生率较低相关。
背景：本研究中人类参与者的数据是根据《赫尔辛基宣言》进行的。本研究已获同济医学院伦理委员会批准,华中科技大学,武汉,中国（[2017]编号S225).所有参与者在登记前提供书面知情同意书。声明确认所有方法均按照相关准则和规定进行。
