Abstract：
Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.
摘要：
人类在许多神经发育障碍和神经退行性疾病的患病率中表现出性别差异。这里,我们为恒河猴生成了最大的多脑区域批量转录数据集之一,并表征了性别偏倚基因表达模式,以研究该物种对性别偏倚神经系统疾病的可译性.我们识别出与人类相似的模式，这与重叠的监管机制有关，生物过程，和性别偏见人类疾病的基因，包括自闭症。我们还表明，性别偏倚基因表现出更大的表达遗传变异和更多的组织特异性表达模式，这可能有助于性别偏见基因的快速进化。我们的发现为性别偏见疾病的生物学机制提供了见解，并支持恒河猴模型用于这些条件的转化研究。
