{Reference Type}: Journal Article
{Title}: Evolutionary and biomedical implications of sex differences in the primate brain transcriptome.
{Author}: DeCasien AR;Chiou KL;Testard C;Mercer A;Negrón-Del Valle JE;Bauman Surratt SE;González O;Stock MK;Ruiz-Lambides AV;Martínez MI; ;Antón SC;Walker CS;Sallet J;Wilson MA;Brent LJN;Montague MJ;Sherwood CC;Platt ML;Higham JP;Snyder-Mackler N;
{Journal}: Cell Genom
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 25
暂无{DOI}: 10.1016/j.xgen.2024.100589
{Abstract}: Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.