%0 Journal Article
%T Evolutionary and biomedical implications of sex differences in the primate brain transcriptome.
%A DeCasien AR
%A Chiou KL
%A Testard C
%A Mercer A
%A Negrón-Del Valle JE
%A Bauman Surratt SE
%A González O
%A Stock MK
%A Ruiz-Lambides AV
%A Martínez MI
%A  
%A Antón SC
%A Walker CS
%A Sallet J
%A Wilson MA
%A Brent LJN
%A Montague MJ
%A Sherwood CC
%A Platt ML
%A Higham JP
%A Snyder-Mackler N
%J Cell Genom
%V 0
%N 0
%D 2024 Jun 25
%M 38942023
暂无%R 10.1016/j.xgen.2024.100589
%X Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.