UNASSIGNED: Participants were adults ages 55-80 with diary-reported sleep efficiency <90% and wake after sleep onset (WASO) >20 min. Sleep diary, actigraphy, polysomnography (PSG), and paired associate memory acquisition and retention were assessed before and after a week-long TiB restriction intervention (n = 30). TiB was restricted to 75% of diary-reported habitual TiB. A comparison group of n = 5 participants repeated assessments while following their usual sleep schedule to obtain preliminary estimates of effect sizes associated with repeated testing.
UNASSIGNED: Subjective and objective sleep measures robustly improved in the TiB restriction group for sleep quality, sleep depth, sleep efficiency and WASO, at the expense of TiB and time spent in N1 and N2 sleep. As hypothesized, SWA increased robustly with TiB restriction across the 0.5-4 Hz range, as well as subjective sleep depth, subjective and objective WASO. Despite increases in sleepiness ratings, no impairments were found in memory acquisition or retention.
UNASSIGNED: A TiB restriction dose equivalent to 75% of habitual TiB robustly increased sleep continuity and SWA in older adults with sleep maintenance difficulties, without impairing memory performance. These findings may inform long-term behavioral SWA enhancement interventions aimed at improving memory performance and risk for cognitive impairments.
■参与者为55-80岁的成年人,日记报告的睡眠效率<90%,睡眠开始后(WASO)>20分钟。睡眠日记,肌动学,多导睡眠图(PSG),在为期一周的TiB限制干预之前和之后,评估了配对的相关记忆获取和保留(n=30)。TiB被限制为日记报告的习惯性TiB的75%。n=5名参与者的比较组重复评估,同时遵循他们通常的睡眠时间表,以获得与重复测试相关的效应大小的初步估计。
■TIB限制组睡眠质量的主观和客观睡眠措施得到了有力改善,睡眠深度,睡眠效率和WASO,以TiB和N1和N2睡眠时间为代价。正如假设的那样,SWA随着TiB限制在0.5-4Hz范围内强劲增加,以及主观睡眠深度,主观和客观的WASO。尽管嗜睡评分有所增加,没有发现记忆获取或记忆保留方面的损伤.
■在睡眠维持困难的老年人中,相当于习惯性TiB的75%的TiB限制剂量强烈增加了睡眠连续性和SWA,而不会损害内存性能。这些发现可能会为旨在改善记忆表现和认知障碍风险的长期行为SWA增强干预提供信息。