PDF(Pubmed)
Abstract：
Implanted biomaterials have transformed healthcare and the treatment of injury and disease, but their influence on the local immune landscape remains unclear. Here we discovered that degradation-resistant titanium-based implants establish an immunosuppressive microenvironment by recruiting myeloid cells, including monocytes, macrophages, neutrophils, and myeloid-lineage dendritic cells. Unlike normal tissues, the tissues nearby implants exhibit an chronic inflamed and immunosuppressive status characterised by myeloid-rich, T cell-exhaustion gene signature by single-cell RNA sequencing. Vitamin C treatment provides an effective strategy to rescue the immunosuppressive microenvironment, which can be used as a regular supplement to reduce the risk of malignant cell survival around the implants.
摘要：
植入的生物材料改变了医疗保健以及伤害和疾病的治疗，但它们对局部免疫景观的影响仍不清楚。在这里，我们发现抗降解钛基植入物通过招募骨髓细胞建立免疫抑制微环境，包括单核细胞,巨噬细胞，中性粒细胞，和骨髓系树突状细胞。与正常组织不同,植入物附近的组织表现出慢性发炎和免疫抑制状态，其特征是富含骨髓，通过单细胞RNA测序的T细胞耗尽基因签名。维生素C治疗提供了拯救免疫抑制微环境的有效策略，可以用作常规补充剂，以降低植入物周围恶性细胞存活的风险。
