%0 Journal Article
%T Degradation-resistant implanted biomaterials establish an immunosuppressive microenvironment that induces T cell exhaustion by recruiting myeloid cells.
%A Fan Q
%A Dai H
%A Bai J
%A Xu J
%A Ma Q
%A Fei Z
%A Zhou X
%A Leong KW
%A Wang C
%J Fundam Res
%V 2
%N 4
%D 2022 Jul
%M 38933993
暂无%R 10.1016/j.fmre.2021.10.007
%X Implanted biomaterials have transformed healthcare and the treatment of injury and disease, but their influence on the local immune landscape remains unclear. Here we discovered that degradation-resistant titanium-based implants establish an immunosuppressive microenvironment by recruiting myeloid cells, including monocytes, macrophages, neutrophils, and myeloid-lineage dendritic cells. Unlike normal tissues, the tissues nearby implants exhibit an chronic inflamed and immunosuppressive status characterised by myeloid-rich, T cell-exhaustion gene signature by single-cell RNA sequencing. Vitamin C treatment provides an effective strategy to rescue the immunosuppressive microenvironment, which can be used as a regular supplement to reduce the risk of malignant cell survival around the implants.