{Reference Type}: Journal Article
{Title}: Degradation-resistant implanted biomaterials establish an immunosuppressive microenvironment that induces T cell exhaustion by recruiting myeloid cells.
{Author}: Fan Q;Dai H;Bai J;Xu J;Ma Q;Fei Z;Zhou X;Leong KW;Wang C;
{Journal}: Fundam Res
{Volume}: 2
{Issue}: 4
{Year}: 2022 Jul
暂无{DOI}: 10.1016/j.fmre.2021.10.007
{Abstract}: Implanted biomaterials have transformed healthcare and the treatment of injury and disease, but their influence on the local immune landscape remains unclear. Here we discovered that degradation-resistant titanium-based implants establish an immunosuppressive microenvironment by recruiting myeloid cells, including monocytes, macrophages, neutrophils, and myeloid-lineage dendritic cells. Unlike normal tissues, the tissues nearby implants exhibit an chronic inflamed and immunosuppressive status characterised by myeloid-rich, T cell-exhaustion gene signature by single-cell RNA sequencing. Vitamin C treatment provides an effective strategy to rescue the immunosuppressive microenvironment, which can be used as a regular supplement to reduce the risk of malignant cell survival around the implants.