PDF(Pubmed)
Abstract：
An increase in chronic, non-responsive bovine respiratory disease (BRD) infections in North American feedlot cattle is observed each fall, a time when cattle are administered multiple antimicrobial treatments for BRD. A number of factors are responsible for BRD antimicrobial treatment failure, with formation of biofilms possibly being one. It is widely accepted that biofilms play a role in chronic infections in humans and it has been hypothesized that they are the default lifestyle of most bacteria. However, research on bacterial biofilms associated with livestock is scarce and significant knowledge gaps exist in our understanding of their role in AMR of the bacterial BRD complex. The four main bacterial species of the BRD complex, Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis are able to form biofilms in vitro and there is evidence that at least H. somni retains this ability in vivo. However, there is a need to elucidate whether their biofilm-forming ability contributes to pathogenicity and antimicrobial treatment failure of BRD. Overall, a better understanding of the possible role of BRD bacterial biofilms in clinical disease and AMR could assist in the prevention and management of respiratory infections in feedlot cattle. We review and discuss the current knowledge of BRD bacteria biofilm biology, study methodologies, and their possible relationship to AMR.
摘要：
慢性的增加，每年秋天在北美饲养场牛中观察到无反应的牛呼吸道疾病（BRD）感染，牛对BRD进行多种抗菌治疗的时间。许多因素导致BRD抗菌治疗失败，生物膜的形成可能是其中之一。生物膜在人类慢性感染中起作用已被广泛接受，并且已经假设它们是大多数细菌的默认生活方式。然而,对与家畜相关的细菌生物膜的研究很少，在我们对它们在细菌BRD复合体的AMR中的作用的理解中存在显著的知识空白。BRD复合体的四种主要细菌，Mannheimia溶血病,多杀性巴氏杆菌,嗜血杆菌,和牛支原体能够在体外形成生物膜，并且有证据表明至少H.somni在体内保留了这种能力。然而,有必要阐明其生物膜形成能力是否有助于BRD的致病性和抗微生物治疗失败。总的来说,更好地了解BRD细菌生物膜在临床疾病和AMR中的可能作用可能有助于预防和管理饲养场牛的呼吸道感染.我们回顾并讨论了BRD细菌生物膜生物学的最新知识，研究方法，以及它们与AMR的可能关系。
