Abstract：
A major worldwide health problem, Helicobacter Pylori (H. pylori) infection is associated with a number of gastrointestinal disorders, such as gastric cancer and peptic ulcers. The shortcomings of traditional treatment plans often include adverse effects, low patient compliance, and the emergence of antibiotic resistance. Investigating different delivery methods is thus necessary to improve the effectiveness of treatment. Mucoadhesive microspheres show promise as a method for delivering anti H. pylori drugs in a targeted and sustained manner. With their ability to stick to the stomach mucosa, these microspheres increase the local concentration of the medication and guarantee a more thorough removal of the pathogen. The potential of Mucoadhesive microspheres in the management of H. pylori infection is examined in this review. We explore the properties and benefits of Mucoadhesive polymers, the production techniques for microspheres, and the variables affecting their functionality. To provide a thorough grasp of this delivery system, a variety of drug-loading strategies, release mechanisms, and in vitro and in vivo assessment methodologies are covered. The potential of Mucoadhesive microspheres to overcome the drawbacks of traditional therapy is shown by highlighting recent developments in their formulation and their therapeutic consequences. Mucoadhesive microspheres constitute an important advancement in the treatment of Helicobacter pylori because they guarantee a regulated release of antibiotics and improve medication absorption at the site of infection. In order to fully appreciate the advantages of this novel delivery method, further study is necessary. Future research paths and the difficulties in the clinical translation of this technology are also discussed.
摘要：
一个世界性的重大健康问题，幽门螺杆菌(H.幽门螺杆菌)感染与许多胃肠道疾病有关，如胃癌和消化性溃疡。传统治疗计划的缺点往往包括不良影响，患者依从性低,以及抗生素耐药性的出现。因此,研究不同的递送方法对于提高治疗的有效性是必要的。粘膜粘附微球显示出作为以靶向和持续方式递送抗幽门螺杆菌药物的方法的前景。凭借它们粘在胃粘膜上的能力，这些微球增加了药物的局部浓度，并保证了病原体的更彻底去除。这篇综述研究了粘膜粘附微球在幽门螺杆菌感染管理中的潜力。我们探索了粘粘聚合物的性能和优点，微球的生产技术，以及影响其功能的变量。为了全面掌握这一交付系统，各种药物装载策略，释放机制，涵盖了体外和体内评估方法。通过强调其配方及其治疗效果的最新发展，显示了粘膜粘附性微球克服传统疗法缺点的潜力。粘膜粘附微球是治疗幽门螺杆菌的重要进步，因为它们保证了抗生素的受控释放并改善了感染部位的药物吸收。为了充分理解这种新颖的递送方法的优点，需要进一步研究。还讨论了该技术未来的研究路径和临床翻译中的困难。
