PDF(Pubmed)
Abstract：
Probiotics are posited to enhance exercise performance by influencing muscle protein synthesis, augmenting glycogen storage, and reducing inflammation. This double-blind study randomized 88 participants to receive a six-week intervention with either a placebo, Lactococcus lactis subsp. lactis LY-66, Lactobacillus plantarum PL-02, or a combination of both strains, combined with a structured exercise training program. We assessed changes in maximal oxygen consumption (VO2max), exercise performance, and gut microbiota composition before and after the intervention. Further analyses were conducted to evaluate the impact of probiotics on exercise-induced muscle damage (EIMD), muscle integrity, and inflammatory markers in the blood, 24 and 48 h post-intervention. The results demonstrated that all probiotic groups exhibited significant enhancements in exercise performance and attenuation of muscle strength decline post-exercise exhaustion (p < 0.05). Notably, PL-02 intake significantly increased muscle mass, whereas LY-66 and the combination therapy significantly reduced body fat percentage (p < 0.05). Analysis of intestinal microbiota revealed an increase in beneficial bacteria, especially a significant rise in Akkermansia muciniphila following supplementation with PL-02 and LY-66 (p < 0.05). Overall, the combination of exercise training and supplementation with PL-02, LY-66, and their combination improved muscle strength, explosiveness, and endurance performance, and had beneficial effects on body composition and gastrointestinal health, as evidenced by data obtained from non-athlete participants.
摘要：
益生菌被认为可以通过影响肌肉蛋白质合成来增强运动表现，增加糖原储存，减少炎症。这项双盲研究随机分配了88名参与者，接受为期6周的安慰剂干预。乳酸乳球菌亚种。乳酸LY-66，植物乳杆菌PL-02，或两种菌株的组合，结合结构化的锻炼训练计划。我们评估了最大耗氧量(VO2max)的变化，锻炼表现，干预前后的肠道菌群组成。进行了进一步的分析，以评估益生菌对运动诱发的肌肉损伤（EIMD）的影响，肌肉完整性,和血液中的炎症标记物，干预后24和48小时。结果表明，所有益生菌组均表现出运动表现的显着增强和运动后精疲力竭的肌肉力量下降的减弱（p<0.05）。值得注意的是,PL-02摄入量显着增加肌肉质量，而LY-66和联合治疗显著降低体脂百分比(p<0.05)。对肠道微生物群的分析显示有益细菌的增加，特别是在补充PL-02和LY-66后，Akkermansia粘液性蛋白显着增加（p<0.05）。总的来说,运动训练和补充PL-02，LY-66及其组合的组合改善了肌肉力量，爆炸性,和耐力性能，并对身体成分和胃肠道健康产生有益影响，从非运动员参与者获得的数据证明了这一点。
