PDF(Pubmed)
Abstract：
The objective was to investigate associations of serum vitamin D concentration with depressive symptoms and assess the impact that vitamin D concentration has on the occurrence of depressive symptoms in 20-44-year-old pregnant women, postpartum women, non-pp women (non-pregnant/postpartum women), and men, including a separate subgroup analysis of postpartum breastfeeding and non-breastfeeding women. The study populations were selected from the 2007-2018 NHANES public data. Subjective interview data and objective laboratory data including depressive symptoms, serum vitamin D concentration, nutrient intake, and demographic information were utilized. Two diet patterns were created using principal component analysis, and a Bayesian multinomial model was fit to predict the depression outcomes for each subpopulation. The estimates for the log vitamin D slope parameter were negative for all cohorts; as vitamin D increased, the probability of having no depression increased, while the probability of depression decreased. The pregnant cohort had the steepest vitamin D slope, followed by postpartum women, then non-pp women and men. Higher vitamin D concentration had more impact on decreasing depression risk in pregnant and postpartum women compared to non-pp women and men. Among postpartum women, higher vitamin D concentration had a greater influence on decreasing breastfeeding women\'s depression risk than non-breastfeeding women.
摘要：
目的是调查血清维生素D浓度与抑郁症状的关系，并评估维生素D浓度对20-44岁孕妇抑郁症状发生的影响。产后妇女，非pp妇女（非怀孕/产后妇女），和男人，包括对产后母乳喂养和非母乳喂养妇女的单独亚组分析。研究人群选自2007-2018年NHANES公开数据。主观访谈数据和客观实验室数据，包括抑郁症状，血清维生素D浓度,营养素摄入量，和人口统计信息被利用。使用主成分分析创建了两种饮食模式，并采用贝叶斯多项式模型来预测每个亚群的抑郁结果。对所有队列的对数维生素D斜率参数的估计均为负；随着维生素D的增加，没有抑郁的可能性增加了，而抑郁症的可能性下降。怀孕的队列有最陡的维生素D斜率，其次是产后妇女，然后是非人民党的男女。与非PP女性和男性相比，较高的维生素D浓度对降低孕妇和产后女性抑郁风险的影响更大。在产后妇女中，与未母乳喂养的女性相比,较高的维生素D浓度对降低母乳喂养女性抑郁风险的影响更大.
