PDF(Pubmed)
Abstract：
Evidence is emerging on the role of maternal diet, gut microbiota, and other lifestyle factors in establishing lifelong health and disease, which are determined by transgenerationally inherited epigenetic modifications. Understanding epigenetic mechanisms may help identify novel biomarkers for gestation-related exposure, burden, or disease risk. Such biomarkers are essential for developing tools for the early detection of risk factors and exposure levels. It is necessary to establish an exposure threshold due to nutrient deficiencies or other environmental factors that can result in clinically relevant epigenetic alterations that modulate disease risks in the fetus. This narrative review summarizes the latest updates on the roles of maternal nutrients (n-3 fatty acids, polyphenols, vitamins) and gut microbiota on the placental epigenome and its impacts on fetal brain development. This review unravels the potential roles of the functional epigenome for targeted intervention to ensure optimal fetal brain development and its performance in later life.
摘要：
关于母亲饮食的作用的证据正在出现，肠道菌群，以及建立终身健康和疾病的其他生活方式因素，它们是由跨代遗传的表观遗传修饰决定的。了解表观遗传机制可能有助于确定妊娠相关暴露的新型生物标志物。负担，或疾病风险。此类生物标志物对于开发用于早期检测风险因素和暴露水平的工具至关重要。由于营养缺乏或其他环境因素，有必要建立暴露阈值，这些因素可能导致临床相关的表观遗传改变，从而调节胎儿的疾病风险。这篇叙述性综述总结了关于母体营养素(n-3脂肪酸，多酚，维生素）和肠道菌群对胎盘表观基因组的影响及其对胎儿大脑发育的影响。这篇综述揭示了功能表观基因组在靶向干预中的潜在作用，以确保胎儿大脑的最佳发育及其在以后生活中的表现。
