PDF(Pubmed)
Abstract：
Turmeric (Curcuma longa) contains curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Nevertheless, curcumin is the most researched active ingredient for its numerous pharmacological effects. We investigated the impact of these curcuminoids found in Ryudai gold, an approved cultivar of Curcuma longa, on wound healing, inflammation, and diabetes. Sub-planter injections of carrageenan induced acute paw inflammation in rats. The wound-healing ability of 1% curcuminoids was examined by making a 6 mm round wound on the shaved dorsum of the mice with a biopsy punch. A single intraperitoneal injection of streptozotocin (50 mg/kg) was used to induce diabetes in mice. Curcuminoids at a dose rate of 100 mg/kg body weight were used with feed and as a gastric gavage to treat diabetes and inflammation in experimental animals. Paw thickness was measured at 1, 3, and 6 h following carrageenan injection. After three hours, mean paw volume was 58% in carrageenan-injected mice, which was 35%, 37%, and 31% in the curcumin, DMC, and BDMC groups, respectively. Histopathology of the paw tissue demonstrated severe infiltration of inflammatory cells and thickening of the dermis, which were remarkably improved by the curcuminoids. The wound-healing abilities were significantly higher in the curcumin- (95.0%), DMC- (93.17%), and BDMC-treated (89.0%) groups, in comparison to that of the control (65.09%) group at day nine. There were no significant differences in wound-healing activity among the groups treated with 1% curcuminoids throughout the study. Streptozotocin-induced diabetes was characterized by an increased blood glucose (552.2 mg/dL) and decreased body weight (31.2 g), compared to that of the control rats (145.6 mg/dL and 46.8 g blood glucose and body weight, respectively). It also caused an increase in serum alanine aminotransferase (ALT; 44.2 U/L) and aspartate aminotransferase (AST; 55.8 U/L) compared to that of the control group (18.6 U/L and 20.1 U/L, respectively). Histopathological examination of the liver showed that diabetes caused hepatic cellular necrosis, congestion of the central vein, and parenchymatous degeneration. However, all three curcuminoids significantly decreased blood glucose levels, ALT, and AST and improved the histopathological score of the liver. These results evidenced that not only curcumin but also DMC and BDMC have potent anti-inflammatory, wound healing, and anti-diabetic efficacy, and the Ryudai gold variety of turmeric could be used as a functional food supplement.
摘要：
姜黄（姜黄）含有姜黄素，去甲氧基姜黄素（DMC），和双去甲氧基姜黄素(BDMC)。然而，姜黄素是研究最多的活性成分，具有多种药理作用。我们调查了在Ryudai黄金中发现的这些姜黄素的影响，一种已批准的姜黄品种，伤口愈合，炎症,和糖尿病。种植者下注射角叉菜胶诱导大鼠急性爪炎。通过用活检打孔器在小鼠的剃毛背部上制作6mm圆形伤口来检查1%姜黄素的伤口愈合能力。使用单次腹膜内注射链脲佐菌素（50mg/kg）在小鼠中诱导糖尿病。以100mg/kg体重的剂量率使用类姜黄素与饲料一起使用,并作为胃管饲以治疗实验动物的糖尿病和炎症。在角叉菜胶注射后1、3和6小时测量爪厚度。三个小时后,注射角叉菜胶的小鼠平均爪体积为58%，是35%,37%,还有31%的姜黄素,DMC,和BDMC组，分别。爪组织的组织病理学显示严重的炎症细胞浸润和真皮增厚，姜黄素得到了显着改善。姜黄素的伤口愈合能力明显更高（95.0％），DMC-（93.17%），和BDMC治疗组（89.0％），与第9天的对照组（65.09％）相比。在整个研究中,用1%类姜黄素处理的组之间的伤口愈合活性没有显著差异。链脲佐菌素诱导的糖尿病的特征是血糖升高（552.2mg/dL）和体重下降（31.2g）。与对照组大鼠相比（145.6mg/dL和46.8g血糖和体重，分别)。与对照组相比，它还导致血清丙氨酸氨基转移酶（ALT;44.2U/L）和天冬氨酸氨基转移酶（AST;55.8U/L）升高（18.6U/L和20.1U/L，分别)。肝脏组织病理学检查显示，糖尿病引起肝细胞坏死，中央静脉充血,和薄壁组织变性。然而,所有三种姜黄素均显着降低血糖水平，ALT,和AST，并改善肝脏的组织病理学评分。这些结果证明，不仅姜黄素而且DMC和BDMC具有有效的抗炎作用，伤口愈合，和抗糖尿病功效，姜黄的Ryudai黄金品种可以用作功能性食品补充剂。
