许多介入研究揭示了姜黄素补充剂对炎症的有益影响,氧化应激,和内皮功能生物标志物,但是调查结果仍然不一致。因此,这项研究是为了研究补充姜黄素对炎症的影响,氧化应激,和内皮功能生物标志物。通过搜索PubMed,Embase,Scopus,和WebofScience截至2024年3月31日。21个荟萃分析的汇总估计显示,姜黄素显着降低CRP(加权平均差异(WMD)=-0.87;95%CI:-1.14,-0.59,P<0.001),肿瘤坏死因子-α(TNF-α)(WMD=-2.72;95%CI:-4.05,-1.38;P<0.001),白细胞介素-6(IL-6)(WMD=-0.97,95%CI:-1.40,-0.54;P<0.001),丙二醛(MDA)(效应大小(ES)=-0.81;95%CI:-1.39,-0.23,P=0.006)和脉搏波传导速度(PWV)(WMD=-45.60;95%CI:-88.16,-3.04,P=0.036),流量介导的扩张(FMD)增加(WMD=1.64,95%CI:1.06,2.22,P<0.001),过氧化氢酶(CAT)(WMD=10.26;95%CI:0.92,19.61,P=0.03),谷胱甘肽过氧化物酶(GPx)(WMD=8.90;95%CI:6.62,11.19,P<0.001),和超氧化物歧化酶(SOD)水平(WMD=20.51;95%CI:7.35,33.67,P=0.002,SMD=0.82;95%CI:0.27,1.38,P=0.004)。然而,姜黄素没有显著改变总抗氧化能力(TAC)(ES=0.29;95%CI:-0.09,0.66,P=0.059)。这些结果表明,姜黄素对CRP有有益的作用,IL-6,TNF-α,SOD,GPx,CAT,MDA,PWV,和口蹄疫水平,可能是改善炎症的有效辅助疗法,氧化应激,和内皮功能。注册号:PROSPERO,CRD42024539018.
Numerous interventional studies have revealed the beneficial impact of
curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers, but the findings are still inconsistent. Thus, this study was conducted to investigate the effects of
curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers. A meta-analysis of randomized clinical trials was performed by searching PubMed, Embase, Scopus, and Web of Science up to March 31, 2024. Pooled estimates of 21 meta-analyses revealed that
curcumin significantly reduced CRP (weighted mean difference (WMD) = -0.87; 95% CI: - 1.14, - 0.59, P< 0.001), tumor-necrosis factor-alpha (TNF-α) (WMD = -2.72; 95% CI: -4.05, -1.38; P< 0.001), interleukin-6 (IL-6) (WMD = -0.97, 95% CI: -1.40, -0.54; P< 0.001), malondialdehyde (MDA) (Effect size (ES) = -0.81; 95% CI: -1.39, -0.23, P = 0.006) and pulse wave velocity (PWV) (WMD = -45.60; 95% CI: -88.16, -3.04, P = 0.036), and increased flow-mediated dilation (FMD) (WMD = 1.64, 95% CI: 1.06, 2.22, P < 0.001), catalase (CAT) (WMD = 10.26; 95% CI: 0.92, 19.61, P= 0.03), glutathione peroxidase (GPx) (WMD = 8.90; 95% CI: 6.62, 11.19, P <0.001), and superoxide dismutase (SOD) levels (WMD = 20.51; 95% CI: 7.35, 33.67, P= 0.002 and SMD = 0.82; 95% CI: 0.27, 1.38, P= 0.004). However,
curcumin did not significantly change total antioxidant capacity (TAC) (ES = 0.29; 95% CI: -0.09, 0.66, P= 0.059). These results suggest that
curcumin has a beneficial effect on CRP, IL-6, TNF-α, SOD, GPx, CAT, MDA, PWV, and FMD levels and may be an effective adjunctive therapy for improving inflammation, oxidative stress, and endothelial function. Registration number: PROSPERO, CRD42024539018.