PDF(Pubmed)
Abstract：
Dermacoccus barathri is the first reported pathogen within the Dermacoccus genus to cause a catheter-related bloodstream infection, which occurred in 2015. In this study, the complete genome assembly of Dermacoccus barathri was constructed, and the complete genome of Dermacoccus barathri FBCC-B549 consists of a single chromosome (3,137,745 bp) without plasmids. The constructed genome of D. barathri was compared with those of two closely related species within the Dermacoccus genus. D. barathri exhibited a pattern similar to Dermacoccus abyssi in terms of gene clusters and synteny analysis. Contrary to previous studies, biosynthetic gene cluster (BGC) analysis for predicting secondary metabolites revealed the presence of the LAP biosynthesis pathway in the complete genome of D. barathri, predicting the potential synthesis of the secondary metabolite plantazolicin. Furthermore, an analysis to investigate the potential pathogenicity of D. barathri did not reveal any antibiotic resistance genes; however, nine virulence factors were identified in the Virulence Factor Database (VFDB). According to these matching results in the VFDB, despite identifying a few factors involved in biofilm formation, further research is required to determine the actual impact of D. barathri on pathogenicity. The complete genome of D. barathri is expected to serve as a valuable resource for future studies on D. barathri, which currently lack sufficient genomic sequence information.
摘要：
BarathriDermacocus是Dermacocus属中第一个报告的导致导管相关血流感染的病原体。这发生在2015年。在这项研究中,构建了BarathriDermacocus的完整基因组组装，和DermacocusbarathriFBCC-B549的完整基因组由没有质粒的单个染色体（3,137,745bp）组成。将构建的D.barathri基因组与Dermacocus属中两个密切相关的物种的基因组进行了比较。D.barathri在基因簇和同种性分析方面表现出与深渊Dermacocusabysi相似的模式。与以前的研究相反，用于预测次级代谢产物的生物合成基因簇（BGC）分析揭示了在D.barathri的完整基因组中存在LAP生物合成途径，预测次生代谢产物植物唑啉的潜在合成。此外，研究D.barathri潜在致病性的分析没有发现任何抗生素抗性基因；然而，在毒力因子数据库（VFDB）中鉴定了9种毒力因子。根据VFDB中的这些匹配结果，尽管确定了一些与生物膜形成有关的因素，需要进一步的研究来确定D.barathri对致病性的实际影响。D.barathri的完整基因组有望成为D.barathri未来研究的宝贵资源，目前缺乏足够的基因组序列信息。
