PDF(Pubmed)
Abstract：
Background. The objective of this systematic review and meta-analysis was to estimate the proportions of individuals infected with Campylobacter, Escherichia, Salmonella, Shigella, or Yersinia who develop reactive arthritis. Methods. A systematic review was conducted, encompassing English-language articles published before January 2024, sourced from the Embase, PubMed, Scopus, and Web of Science databases. This review included observational studies that reported the occurrence of reactive arthritis (ReA) among patients with Campylobacter, Escherichia, Salmonella, Shigella, or Yersinia infections. Data extraction was carried out independently by two reviewers. Subsequently, a random-effects meta-analysis was performed, with heterogeneity assessed using the I2 value. Additionally, meta-regression was employed to investigate the potential influence of study-level variables on the observed heterogeneity. Results. A total of 87 studies were identified; 23 reported on ReA development after Campylobacter infection, 7 reported on ReA after Escherichia infection, 30 reported ReA onset after salmonellosis, 14 reported ReA after shigellosis, and 13 reported ReA after Yersinia infection. The proportion of Campylobacter patients who developed ReA was 0.03 (95% CI [0.01, 0.06], I2 = 97.62%); the proportion of Escherichia patients who developed ReA was 0.01 (95% CI [0.00, 0.06], I2 = 92.78%); the proportion of Salmonella patients was 0.04 (95% CI [0.02, 0.08], I2 = 97.67%); the proportion of Shigella patients was 0.01 (95% CI [0.01, 0.03], I2 = 90.64%); and the proportion of Yersinia patients who developed ReA was 0.05 (95% CI [0.02, 0.13], I2 = 96%). Conclusion. A significant proportion of Salmonella, Shigella, and Yersinia cases resulted in ReA. Nonetheless, it is important to interpret the findings cautiously due to the substantial heterogeneity observed between studies.
摘要：
背景。本系统评价和荟萃分析的目的是估计感染弯曲杆菌的个体的比例。埃希氏菌,沙门氏菌,志贺氏菌,或耶尔森氏菌会发展为反应性关节炎。方法。进行了系统的审查，包含2024年1月之前发表的英语文章，来自Embase，PubMed,Scopus,和WebofScience数据库。这篇综述包括观察性研究，这些研究报告了弯曲杆菌患者反应性关节炎（ReA）的发生，埃希氏菌,沙门氏菌,志贺氏菌,或耶尔森氏菌感染。数据提取由两名审阅者独立进行。随后，进行了随机效应荟萃分析，使用I2值评估异质性。此外,采用meta回归分析研究水平变量对观察到的异质性的潜在影响。结果。共确定了87项研究；23项报道了弯曲杆菌感染后的ReA发展，7例大肠杆菌感染后的ReA报告，30例报告沙门氏菌病后出现ReA，14在志贺氏菌病后报告了ReA，13例报告了耶尔森氏菌感染后的ReA。出现ReA的弯曲杆菌患者比例为0.03(95%CI[0.01,0.06],I2=97.62%);发生ReA的大肠埃希菌患者比例为0.01(95%CI[0.00,0.06],I2=92.78%);沙门氏菌患者比例为0.04(95%CI[0.02,0.08],I2=97.67%);志贺氏菌患者比例为0.01(95%CI[0.01,0.03],I2=90.64％）；发生ReA的耶尔森氏菌患者比例为0.05（95％CI[0.02，0.13]，I2=96%)。结论。沙门氏菌的比例很大，志贺氏菌,耶尔森氏菌病例导致了ReA。尽管如此，由于研究之间存在显著的异质性,因此谨慎解释研究结果非常重要.
