PDF(Pubmed)
Abstract：
The incorporation of histone variants has structural ramifications on nucleosome dynamics and stability. Due to their unique sequences, histone variants can alter histone-histone or histone-DNA interactions, impacting the folding of DNA around the histone octamer and the overall higher-order structure of chromatin fibers. These structural modifications alter chromatin compaction and accessibility of DNA by transcription factors and other regulatory proteins to influence gene regulatory processes such as DNA damage and repair, as well as transcriptional activation or repression. Histone variants can also generate a unique interactome composed of histone chaperones and chromatin remodeling complexes. Any of these perturbations can contribute to cellular plasticity and the progression of human diseases. Here, we focus on a frequently overlooked group of histone variants lying within the four human histone gene clusters and their contribution to breast cancer.
摘要：
组蛋白变体的掺入对核小体动力学和稳定性具有结构分支。由于它们独特的序列，组蛋白变体可以改变组蛋白-组蛋白或组蛋白-DNA相互作用，影响组蛋白八聚体周围DNA的折叠和染色质纤维的整体高阶结构。这些结构修饰通过转录因子和其他调节蛋白改变染色质压实和DNA的可及性，以影响基因调节过程，如DNA损伤和修复。以及转录激活或抑制。组蛋白变体还可以产生由组蛋白伴侣和染色质重塑复合物组成的独特相互作用体。这些扰动中的任何一种都可以促进细胞可塑性和人类疾病的进展。这里,我们重点关注四个人类组蛋白基因簇中一组经常被忽视的组蛋白变异及其对乳腺癌的影响.
