PDF(Pubmed)
Abstract：
Human endogenous retroviruses (HERVs) are DNA transposable elements that have integrated into the human genome via an ancestral germline infection. The potential importance of HERVs is underscored by the fact that they comprise approximately 8% of the human genome. HERVs have been implicated in the pathogenesis of neurodegenerative diseases, a group of CNS diseases characterized by a progressive loss of structure and function of neurons, resulting in cell death and multiple physiological dysfunctions. Much evidence indicates that HERVs are initiators or drivers of neurodegenerative processes in multiple sclerosis and amyotrophic lateral sclerosis, and clinical trials have been designed to target HERVs. In recent years, the role of HERVs has been explored in other major neurodegenerative diseases, including frontotemporal dementia, Alzheimer\'s disease and Parkinson\'s disease, with some interesting discoveries. This review summarizes and evaluates the past and current research on HERVs in neurodegenerative diseases. It discusses the potential role of HERVs in disease manifestation and neurodegeneration. It critically reviews antiretroviral strategies used in the therapeutic intervention of neurodegenerative diseases.
摘要：
人内源性逆转录病毒(HERV)是通过祖先种系感染整合到人基因组中的DNA转座因子。HERV的潜在重要性由它们占人类基因组的约8%的事实强调。HERV与神经退行性疾病的发病机制有关，一组以神经元结构和功能进行性丧失为特征的中枢神经系统疾病，导致细胞死亡和多种生理功能紊乱。许多证据表明，HERV是多发性硬化症和肌萎缩侧索硬化症中神经退行性过程的启动者或驱动者，和临床试验已被设计为针对HERV。近年来,HERV在其他主要神经退行性疾病中的作用已被探索，包括额颞叶痴呆,阿尔茨海默病和帕金森病,有一些有趣的发现。本文综述了HERV在神经退行性疾病中的过去和现在的研究。它讨论了HERV在疾病表现和神经变性中的潜在作用。它严格回顾了用于神经退行性疾病治疗干预的抗逆转录病毒策略。
