METHODS: The survey encompassed 92 patients from 11 institutes, and assessed histological ML types, treatment regimens, timing of RT relative to auto-PBSCT, and associated adverse events.
RESULTS: The results indicated no significant differences in adverse events, including myelosuppression, based on the timing of RT in relation to auto-PBSCT. However, anemia was more prevalent when RT was administered before auto-PBSCT, and there was a higher incidence of neutropenia recovery delay in patients receiving RT after auto-PBSCT.
CONCLUSIONS: This study provides valuable insights into the variable practices of auto-PBSCT and local RT in ML treatment, emphasizing the need for optimized timing of these therapies to improve patient outcomes and reduce complications.
方法:该调查涵盖了来自11个研究所的92名患者,并评估组织学ML类型,治疗方案,RT相对于自动PBSCT的时序,和相关的不良事件。
结果:结果表明不良事件没有显着差异,包括骨髓抑制,基于RT相对于自动PBSCT的时序。然而,在auto-PBSCT之前给予RT时,贫血更为普遍,在自动PBSCT后接受RT的患者中,中性粒细胞减少症恢复延迟的发生率更高。
结论:这项研究为ML治疗中自动PBSCT和局部RT的可变实践提供了有价值的见解,强调需要优化这些治疗的时机,以改善患者的预后并减少并发症。