PDF(Pubmed)
Abstract：
BACKGROUND: Chronic stress can cause an imbalance within the autonomic nervous system, thereby affecting cardiovascular and mental health. Physical activity (PA) may have a positive effect on the autonomic nervous system and stress-related disorders, such as depression and burnout. Heart rate variability (HRV) is a non-invasive marker of the autonomic nervous system. However, limited and inconsistent data exist on the exact relationship between HRV, PA and depression and burnout symptoms. The HARMODI study aims to explore whether HRV is a feasible marker of depression and burnout symptoms and aims to evaluate the role of PA in the treatment of stress-related disorders.
METHODS: This is an observational study with a cross-sectional up to 8 week follow-up study design. A total of 153 patients, undergoing psychiatric inpatient treatment with burnout syndrome (Z73) and depressive episode (F32 or F33) or adjustment disorder (F43.2), will be recruited. Data on depression and burnout symptoms, HRV recordings (24-hour, supine, standing and exercise stress test), cognitive function, cardiorespiratory fitness, cardiovascular health, balance and strength will be collected at baseline (T1) and after up to 8 weeks (T2). Continuous data on PA and Ecological Momentary Assessments of exhaustion, mood and tension will be monitored daily throughout inpatient treatment. Multiple regression models, adjusted for potential confounders, will assess the association between HRV as the primary outcome, PA and depression and burnout severity score.
BACKGROUND: The protocol has been approved by Swiss Ethics Committee, Cantonal Ethics Committee Zürich. Results of HARMODI will be disseminated through peer-reviewed journals and conference presentations.
BACKGROUND: NCT05874856.
METHODS: This is an observational study with a cross-sectional up to 8 week follow-up study design. A total of 153 patients, undergoing psychiatric inpatient treatment with burnout syndrome (Z73) and depressive episode (F32 or F33) or adjustment disorder (F43.2), will be recruited. Data on depression and burnout symptoms, HRV recordings (24-hour, supine, standing and exercise stress test), cognitive function, cardiorespiratory fitness, cardiovascular health, balance and strength will be collected at baseline (T1) and after up to 8 weeks (T2). Continuous data on PA and Ecological Momentary Assessments of exhaustion, mood and tension will be monitored daily throughout inpatient treatment. Multiple regression models, adjusted for potential confounders, will assess the association between HRV as the primary outcome, PA and depression and burnout severity score.
BACKGROUND: The protocol has been approved by Swiss Ethics Committee, Cantonal Ethics Committee Zürich. Results of HARMODI will be disseminated through peer-reviewed journals and conference presentations.
BACKGROUND: NCT05874856.
摘要：
背景：慢性压力会导致自主神经系统内的失衡，从而影响心血管和心理健康。体力活动（PA）可能对自主神经系统和压力相关疾病产生积极影响，比如抑郁和倦怠。心率变异性（HRV）是自主神经系统的非侵入性标记。然而,HRV之间的确切关系存在有限和不一致的数据，PA和抑郁和倦怠症状。HARMODI研究旨在探讨HRV是否是抑郁症和倦怠症状的可行标志物，并旨在评估PA在治疗压力相关疾病中的作用。
方法：这是一项观察性研究，采用为期8周的横断面随访研究设计。共有153名患者，接受精神科住院治疗伴倦怠综合征（Z73）和抑郁发作（F32或F33）或调整障碍（F43.2），将被招募。关于抑郁和倦怠症状的数据，HRV录音（24小时，仰卧,站立和运动压力测试)，认知功能,心肺健康，心血管健康,平衡和强度将在基线（T1）和长达8周（T2）后收集。有关PA和耗竭的生态瞬时评估的连续数据，在整个住院治疗期间，每天都会监测情绪和紧张。多元回归模型，针对潜在的混杂因素进行了调整，将评估作为主要结果的HRV之间的关联，PA和抑郁和倦怠严重程度评分。
背景：该方案已获得瑞士伦理委员会的批准，州伦理委员会。HARMODI的结果将通过同行评审的期刊和会议演示进行传播。
背景：NCT05874856。
方法：这是一项观察性研究，采用为期8周的横断面随访研究设计。共有153名患者，接受精神科住院治疗伴倦怠综合征（Z73）和抑郁发作（F32或F33）或调整障碍（F43.2），将被招募。关于抑郁和倦怠症状的数据，HRV录音（24小时，仰卧,站立和运动压力测试)，认知功能,心肺健康，心血管健康,平衡和强度将在基线（T1）和长达8周（T2）后收集。有关PA和耗竭的生态瞬时评估的连续数据，在整个住院治疗期间，每天都会监测情绪和紧张。多元回归模型，针对潜在的混杂因素进行了调整，将评估作为主要结果的HRV之间的关联，PA和抑郁和倦怠严重程度评分。
背景：该方案已获得瑞士伦理委员会的批准，州伦理委员会。HARMODI的结果将通过同行评审的期刊和会议演示进行传播。
背景：NCT05874856。
