Abstract：
To evaluate the clinical evidence of platelet-rich plasma (PRP) in the treatment of venous ulcers (VUs). Electronic searches were conducted through the Cochrane Library, Web of Science, Embase and PubMed. AMSTAR-2 was used to assess the methodological quality. The quality of evidence was assessed using the GRADE system. According to AMSTAR-2, the methodological quality of the included reviews was generally inadequate owing to the limitations of entries 2, 4 and 7. Due to bias risk and imprecision, the evidence quality of the outcome measures was inadequate. In conclusion, PRP may have a therapeutic effect on VUs. However, this conclusion must be treated with caution due to methodological flaws of the included systematic reviews and meta-analyses.
摘要：
目的评价富血小板血浆(PRP)治疗静脉性溃疡(VU)的临床证据。通过Cochrane图书馆进行了电子搜索，WebofScience,Embase和PubMed。AMSTAR-2用于评估方法学质量。使用GRADE系统评估证据质量。根据AMSTAR-2，由于条目2、4和7的限制，纳入的审查的方法质量普遍不足。由于偏差风险和不精确，结果测量的证据质量不足.总之,PRP可能对VU具有治疗作用。然而,由于纳入的系统评价和荟萃分析存在方法学缺陷,因此必须谨慎对待这一结论.
