{Reference Type}: Journal Article
{Title}: An overview of systematic reviews of clinical studies of platelet-rich plasma for venous ulcers.
{Author}: Shi T;Hu S;Hui J;Ji Y;Zhang Y;
{Journal}: Wound Repair Regen
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 24
{Factor}: 3.401
{DOI}: 10.1111/wrr.13201
{Abstract}: To evaluate the clinical evidence of platelet-rich plasma (PRP) in the treatment of venous ulcers (VUs). Electronic searches were conducted through the Cochrane Library, Web of Science, Embase and PubMed. AMSTAR-2 was used to assess the methodological quality. The quality of evidence was assessed using the GRADE system. According to AMSTAR-2, the methodological quality of the included reviews was generally inadequate owing to the limitations of entries 2, 4 and 7. Due to bias risk and imprecision, the evidence quality of the outcome measures was inadequate. In conclusion, PRP may have a therapeutic effect on VUs. However, this conclusion must be treated with caution due to methodological flaws of the included systematic reviews and meta-analyses.