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Abstract：
BACKGROUND: To estimate the prevalence of sensory symptoms in people with cerebral palsy (CP) across the lifespan.
METHODS: In this cross-sectional study, the self-reported Sensory Processing Scale Inventory (SPS-I) was administered via Research Electronic Data Capture (REDCap) between February 1, 2022, and August 15, 2022, to people with CP or their caregivers enrolled in the online MyCP Community Registry. We determined the association between SPS-I scores and age (Pearson correlation) and functional status as assessed using five validated functional classification systems for CP (analysis of variance [ANOVA]). We hypothesized that sensory symptoms would differ between younger and older individuals with CP.
RESULTS: Of 155 responses (28% response rate, age one to 76 years, 34% male), 97% reported at least one bothersome sensory symptom. Total sensory symptoms decreased with age (R2 = 0.12, P < 0.0001), driven by decreases in hyposensitivity symptoms (R2 = 0.32, P < 0.0001), primarily tactile hyposensitivity (R2 = 0.29, P < 0.0001). Sensory symptoms increased with greater functional impairment across all functional domains (ANOVA, P < 0.0001). However, the age-specific decrease in hyposensitivities was most pronounced in people with the greatest gross motor functional impairment (R2 = 0.70, P = 0.0004).
CONCLUSIONS: Our findings suggest that hyposensitivity, primarily tactile sensitivity, decreases with age in people with CP. Future work should assess whether decreased hyposensitivity contributes to other age-related changes in CP like increased pain.
METHODS: In this cross-sectional study, the self-reported Sensory Processing Scale Inventory (SPS-I) was administered via Research Electronic Data Capture (REDCap) between February 1, 2022, and August 15, 2022, to people with CP or their caregivers enrolled in the online MyCP Community Registry. We determined the association between SPS-I scores and age (Pearson correlation) and functional status as assessed using five validated functional classification systems for CP (analysis of variance [ANOVA]). We hypothesized that sensory symptoms would differ between younger and older individuals with CP.
RESULTS: Of 155 responses (28% response rate, age one to 76 years, 34% male), 97% reported at least one bothersome sensory symptom. Total sensory symptoms decreased with age (R2 = 0.12, P < 0.0001), driven by decreases in hyposensitivity symptoms (R2 = 0.32, P < 0.0001), primarily tactile hyposensitivity (R2 = 0.29, P < 0.0001). Sensory symptoms increased with greater functional impairment across all functional domains (ANOVA, P < 0.0001). However, the age-specific decrease in hyposensitivities was most pronounced in people with the greatest gross motor functional impairment (R2 = 0.70, P = 0.0004).
CONCLUSIONS: Our findings suggest that hyposensitivity, primarily tactile sensitivity, decreases with age in people with CP. Future work should assess whether decreased hyposensitivity contributes to other age-related changes in CP like increased pain.
摘要：
背景：评估脑瘫（CP）患者在整个生命周期中感觉症状的患病率。
方法：在这项横断面研究中，自报告感觉处理量表(SPS-I)在2022年2月1日至2022年8月15日期间通过研究电子数据捕获(REDCap)对在线MyCP社区登记处登记的CP患者或其护理人员进行了管理.我们确定了SPS-I评分与年龄（Pearson相关性）和功能状态之间的关联，如使用五个经过验证的CP功能分类系统（方差分析[ANOVA]）所评估的。我们假设患有CP的年轻人和老年人之间的感觉症状会有所不同。
结果：在155个响应中（28％的响应率，1岁到76岁,34%男性），97%的人报告了至少一种令人烦恼的感觉症状。总感觉症状随年龄增长而降低(R2=0.12,P<0.0001),由低敏感症状的减少驱动（R2=0.32，P<0.0001），主要是触觉不敏感(R2=0.29,P<0.0001)。感觉症状随着所有功能领域功能受损的增加而增加(方差分析，P<0.0001)。然而,在粗大运动功能障碍最严重的人群中,年龄特异性的低敏感性下降最为明显(R2=0.70,P=0.0004).
结论：我们的研究结果表明，主要是触觉敏感，CP患者随年龄增长而减少。未来的工作应该评估低敏感性降低是否会导致其他与年龄相关的CP变化，如疼痛增加。
方法：在这项横断面研究中，自报告感觉处理量表(SPS-I)在2022年2月1日至2022年8月15日期间通过研究电子数据捕获(REDCap)对在线MyCP社区登记处登记的CP患者或其护理人员进行了管理.我们确定了SPS-I评分与年龄（Pearson相关性）和功能状态之间的关联，如使用五个经过验证的CP功能分类系统（方差分析[ANOVA]）所评估的。我们假设患有CP的年轻人和老年人之间的感觉症状会有所不同。
结果：在155个响应中（28％的响应率，1岁到76岁,34%男性），97%的人报告了至少一种令人烦恼的感觉症状。总感觉症状随年龄增长而降低(R2=0.12,P<0.0001),由低敏感症状的减少驱动（R2=0.32，P<0.0001），主要是触觉不敏感(R2=0.29,P<0.0001)。感觉症状随着所有功能领域功能受损的增加而增加(方差分析，P<0.0001)。然而,在粗大运动功能障碍最严重的人群中,年龄特异性的低敏感性下降最为明显(R2=0.70,P=0.0004).
结论：我们的研究结果表明，主要是触觉敏感，CP患者随年龄增长而减少。未来的工作应该评估低敏感性降低是否会导致其他与年龄相关的CP变化，如疼痛增加。
