Abstract：
UNASSIGNED: Nipah and Hendra viruses belong to the Paramyxoviridae family, which pose a significant threat to human health, with sporadic outbreaks causing severe morbidity and mortality. Early symptoms include fever, cough, sore throat, and headache, which offer little in terms of differential diagnosis. There are no specific therapeutics and vaccines for these viruses.
UNASSIGNED: This review comprehensively covers a spectrum of diagnostic techniques for Nipah and Hendra virus infections, discussed in conjunction with appropriate type of samples during the progression of infection. Serological assays, reverse transcriptase Real-Time PCR assays, and isothermal amplification assays are discussed in detail, along with a listing of few commercially available detection kits. Patents protecting inventions in Nipah and Hendra virus detection are also covered.
UNASSIGNED: Despite several outbreaks of Nipah and Hendra infections in the past decade, in-depth research into their pathogenesis, Point-of-Care diagnostics, specific therapies, and human vaccines is lacking. A prompt and accurate diagnosis is pivotal for efficient outbreak management, patient treatment, and the adoption of preventative measures. The emergence of rapid point-of-care tests holds promise in enhancing diagnostic capabilities in real-world settings. The patent landscape emphasizes the importance of innovation and collaboration within the legal and business realms.
UNASSIGNED: This review comprehensively covers a spectrum of diagnostic techniques for Nipah and Hendra virus infections, discussed in conjunction with appropriate type of samples during the progression of infection. Serological assays, reverse transcriptase Real-Time PCR assays, and isothermal amplification assays are discussed in detail, along with a listing of few commercially available detection kits. Patents protecting inventions in Nipah and Hendra virus detection are also covered.
UNASSIGNED: Despite several outbreaks of Nipah and Hendra infections in the past decade, in-depth research into their pathogenesis, Point-of-Care diagnostics, specific therapies, and human vaccines is lacking. A prompt and accurate diagnosis is pivotal for efficient outbreak management, patient treatment, and the adoption of preventative measures. The emergence of rapid point-of-care tests holds promise in enhancing diagnostic capabilities in real-world settings. The patent landscape emphasizes the importance of innovation and collaboration within the legal and business realms.
摘要：
■Nipah和Hendra病毒属于副粘病毒科，对人类健康构成重大威胁，零星爆发导致严重的发病率和死亡率。早期症状包括发烧，咳嗽,喉咙痛,头痛,在鉴别诊断方面提供的很少。没有针对这些病毒的特异性治疗剂和疫苗。
■这篇综述全面涵盖了一系列尼帕和亨德拉病毒感染的诊断技术，在感染进展过程中结合适当类型的样本进行讨论。血清学测定,逆转录酶实时PCR检测，和等温扩增试验进行了详细讨论，以及一些市售检测试剂盒的列表。还涵盖了保护Nipah和Hendra病毒检测发明的专利。
■尽管在过去十年中多次爆发Nipah和Hendra感染，深入研究其发病机理，即时诊断,特定疗法,人类缺乏疫苗。及时准确的诊断对于有效的爆发管理至关重要，患者治疗,采取预防措施。快速即时测试的出现有望增强现实环境中的诊断能力。专利格局强调了法律和商业领域内创新和合作的重要性。
■这篇综述全面涵盖了一系列尼帕和亨德拉病毒感染的诊断技术，在感染进展过程中结合适当类型的样本进行讨论。血清学测定,逆转录酶实时PCR检测，和等温扩增试验进行了详细讨论，以及一些市售检测试剂盒的列表。还涵盖了保护Nipah和Hendra病毒检测发明的专利。
■尽管在过去十年中多次爆发Nipah和Hendra感染，深入研究其发病机理，即时诊断,特定疗法,人类缺乏疫苗。及时准确的诊断对于有效的爆发管理至关重要，患者治疗,采取预防措施。快速即时测试的出现有望增强现实环境中的诊断能力。专利格局强调了法律和商业领域内创新和合作的重要性。
