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Abstract：
OBJECTIVE: The aim of this study is to analyse whether optical coherence tomography angiography (angio-OCT, OCTA) measurements can be a useful tool to differentiate central nervous system (CNS) involvement in rheumatic disorders (RD) from multiple sclerosis (MS).
METHODS: A total of 85 patients- 41 with MS, 21 with RD with CNS involvement and 23 healthy controls were included in the study. All individuals underwent OCTA and the following parameters were measured in each eye separately: average foveal and parafoveal vessel density (VD), average foveal and parafoveal vessel length (VL) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as well as area, perimeter, and circularity of the foveal avascular zone.
RESULTS: OCTA showed a VD reduction in the foveal region of the SCP in eyes of RD patients when compared to MS patients (21.96 ± 3.39 vs.23.88 ± 3.05 (p = 0.003)). There have been no significant differences in any of the assessed parameters that is average VD and total average VL in the foveal area of the SCP as well as of the DCP in the general population comprising healthy controls, MS and RD groups (p > 0.05 for all).
CONCLUSIONS: Our results suggest that an OCTA finding of decreased VD in the foveal region of the SCP may be considered as a potentially useful biomarker of RD in comparison with MS patients.
METHODS: A total of 85 patients- 41 with MS, 21 with RD with CNS involvement and 23 healthy controls were included in the study. All individuals underwent OCTA and the following parameters were measured in each eye separately: average foveal and parafoveal vessel density (VD), average foveal and parafoveal vessel length (VL) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as well as area, perimeter, and circularity of the foveal avascular zone.
RESULTS: OCTA showed a VD reduction in the foveal region of the SCP in eyes of RD patients when compared to MS patients (21.96 ± 3.39 vs.23.88 ± 3.05 (p = 0.003)). There have been no significant differences in any of the assessed parameters that is average VD and total average VL in the foveal area of the SCP as well as of the DCP in the general population comprising healthy controls, MS and RD groups (p > 0.05 for all).
CONCLUSIONS: Our results suggest that an OCTA finding of decreased VD in the foveal region of the SCP may be considered as a potentially useful biomarker of RD in comparison with MS patients.
摘要：
目的：本研究的目的是分析光学相干断层扫描血管造影（血管OCT，OCTA）测量可以是区分中枢神经系统（CNS）与风湿性疾病（RD）和多发性硬化症（MS）的有用工具。
方法：共85例患者-41例MS，本研究包括21例参与CNS的RD和23例健康对照。所有个体都接受了OCTA，并分别测量了每只眼睛的以下参数：平均中央凹和副凹血管密度（VD），浅表毛细血管丛（SCP）和深毛细血管丛（DCP）的平均中央凹和副凹血管长度（VL），以及区域,周边,和中央凹无血管区的圆度。
结果：OCTA显示与MS患者相比，RD患者眼中SCP中心凹区域的VD降低（21.96±3.39vs.23.88±3.05（p=0.003））。在包括健康对照的一般人群中，SCP和DCP的中央凹区域的平均VD和总平均VL的任何评估参数没有显着差异，MS和RD组(均p>0.05)。
结论：我们的结果表明，与MS患者相比，OCTA发现SCP中央凹区域VD降低可能被认为是RD的潜在有用生物标志物。
方法：共85例患者-41例MS，本研究包括21例参与CNS的RD和23例健康对照。所有个体都接受了OCTA，并分别测量了每只眼睛的以下参数：平均中央凹和副凹血管密度（VD），浅表毛细血管丛（SCP）和深毛细血管丛（DCP）的平均中央凹和副凹血管长度（VL），以及区域,周边,和中央凹无血管区的圆度。
结果：OCTA显示与MS患者相比，RD患者眼中SCP中心凹区域的VD降低（21.96±3.39vs.23.88±3.05（p=0.003））。在包括健康对照的一般人群中，SCP和DCP的中央凹区域的平均VD和总平均VL的任何评估参数没有显着差异，MS和RD组(均p>0.05)。
结论：我们的结果表明，与MS患者相比，OCTA发现SCP中央凹区域VD降低可能被认为是RD的潜在有用生物标志物。
