Abstract：
This meta-analysis evaluated the impact of prophylactic post-chemotherapy granulocyte colony-stimulating factor (G-CSF) in patients with acute myeloid leukemia (AML). Overall, the relapse rate, overall survival, event-free survival, and mortality rate were similar in G-CSF (+) compared to G-CSF (-) patients. However, the relative risk (RR) of relapse was higher in children and in secondary AML patients who were treated with G-CSF compared to the G-CSF (-) group [RR, 95% confidence interval: 1.26, 1.04-1.52, and 1.12 (1.02-1.24)]. Treatment with post-chemotherapy G-CSF should be prescribed with caution in pediatric patients with AML and secondary AML as possibly increasing the relapse risk.
摘要：
这项荟萃分析评估了预防性化疗后粒细胞集落刺激因子（G-CSF）对急性髓细胞性白血病（AML）患者的影响。总的来说,复发率,总生存率,无事件生存，G-CSF(+)与G-CSF(-)患者的死亡率相似.然而,与G-CSF（-）组相比，接受G-CSF治疗的儿童和继发性AML患者的相对复发风险（RR）更高[RR，95%置信区间：1.26、1.04-1.52和1.12(1.02-1.24)]。对于患有AML和继发性AML的儿科患者，应谨慎使用化疗后G-CSF治疗，因为这可能会增加复发风险。
