{Reference Type}: Journal Article
{Title}: The Impact of Prophylactic Post-Chemotherapy G-CSF on the Relapse Rates in Patients with Acute Myeloid Leukemia: A Meta-Analysis.
{Author}: Bordbar M;Hosseini-Bensenjan M;Sayadi M;Zekavat O;Bordbar S;Nozari F;Haghpanah S;
{Journal}: Cancer Invest
{Volume}: 42
{Issue}: 6
{Year}: 2024 Jul 26
{Factor}: 2.368
{DOI}: 10.1080/07357907.2024.2352454
{Abstract}: This meta-analysis evaluated the impact of prophylactic post-chemotherapy granulocyte colony-stimulating factor (G-CSF) in patients with acute myeloid leukemia (AML). Overall, the relapse rate, overall survival, event-free survival, and mortality rate were similar in G-CSF (+) compared to G-CSF (-) patients. However, the relative risk (RR) of relapse was higher in children and in secondary AML patients who were treated with G-CSF compared to the G-CSF (-) group [RR, 95% confidence interval: 1.26, 1.04-1.52, and 1.12 (1.02-1.24)]. Treatment with post-chemotherapy G-CSF should be prescribed with caution in pediatric patients with AML and secondary AML as possibly increasing the relapse risk.