%0 Journal Article
%T The Impact of Prophylactic Post-Chemotherapy G-CSF on the Relapse Rates in Patients with Acute Myeloid Leukemia: A Meta-Analysis.
%A Bordbar M
%A Hosseini-Bensenjan M
%A Sayadi M
%A Zekavat O
%A Bordbar S
%A Nozari F
%A Haghpanah S
%J Cancer Invest
%V 42
%N 6
%D 2024 Jul 26
%M 38922312
%F 2.368
%R 10.1080/07357907.2024.2352454
%X This meta-analysis evaluated the impact of prophylactic post-chemotherapy granulocyte colony-stimulating factor (G-CSF) in patients with acute myeloid leukemia (AML). Overall, the relapse rate, overall survival, event-free survival, and mortality rate were similar in G-CSF (+) compared to G-CSF (-) patients. However, the relative risk (RR) of relapse was higher in children and in secondary AML patients who were treated with G-CSF compared to the G-CSF (-) group [RR, 95% confidence interval: 1.26, 1.04-1.52, and 1.12 (1.02-1.24)]. Treatment with post-chemotherapy G-CSF should be prescribed with caution in pediatric patients with AML and secondary AML as possibly increasing the relapse risk.