PDF(Pubmed)
Abstract：
Current evidence suggests that airborne pollutants have a detrimental effect on fetal growth through the emergence of small for gestational age (SGA) or term low birth weight (TLBW). The study\'s objective was to critically evaluate the available literature on the association between environmental pollution and the incidence of SGA or TLBW occurrence. A comprehensive literature search was conducted across Pubmed/MEDLINE, Web of Science, Cochrane Library, EMBASE, and Google Scholar using predefined inclusion and exclusion criteria. The methodology adhered to the PRISMA guidelines. The systematic review protocol was registered in PROSPERO with ID number: CRD42022329624. As a result, 69 selected papers described the influence of environmental pollutants on SGA and TLBW occurrence with an Odds Ratios (ORs) of 1.138 for particulate matter ≤ 10 μm (PM10), 1.338 for particulate matter ≤ 2.5 μm (PM2.5), 1.173 for ozone (O3), 1.287 for sulfur dioxide (SO2), and 1.226 for carbon monoxide (CO). All eight studies analyzed validated that exposure to volatile organic compounds (VOCs) is a risk factor for SGA or TLBW. Pregnant women in the high-risk group of SGA occurrence, i.e., those living in urban areas or close to sources of pollution, are at an increased risk of complications. Understanding the exact exposure time of pregnant women could help improve prenatal care and timely intervention for fetuses with SGA. Nevertheless, the pervasive air pollution underscored in our findings suggests a pressing need for adaptive measures in everyday life to mitigate worldwide environmental pollution.
摘要：
目前的证据表明，空气中的污染物通过出现小于胎龄（SGA）或足月低出生体重（TLBW）对胎儿生长产生不利影响。该研究的目的是批判性地评估有关环境污染与SGA或TLBW发生率之间关联的现有文献。在Pubmed/MEDLINE进行了全面的文献检索，WebofScience,科克伦图书馆,EMBASE,和谷歌学者使用预定义的纳入和排除标准。该方法符合PRISMA准则。系统评价方案在PROSPERO注册，ID号：CRD42022329624。因此,69篇选定的论文描述了环境污染物对SGA和TLBW发生的影响，颗粒物≤10μm（PM10）的赔率（ORs）为1.138，颗粒物≤2.5μm(PM2.5)为1.338,1.173代表臭氧(O3)，1.287二氧化硫(SO2)，一氧化碳(CO)为1.226。分析的所有8项研究都验证了暴露于挥发性有机化合物（VOCs）是SGA或TLBW的危险因素。SGA发生的高危人群中的孕妇，即，那些生活在城市地区或接近污染源的人，并发症的风险增加。了解孕妇的确切暴露时间有助于改善产前护理和对SGA胎儿的及时干预。然而，我们的研究结果中强调的普遍空气污染表明，迫切需要在日常生活中采取适应性措施来减轻全球环境污染。
