PDF(Pubmed)
Abstract：
Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the formation of PML::RARA, an oncogenic fusion protein responsible for blocking myeloid differentiation and survival advantage. Here, we present a case of acute promyelocytic leukemia with two unusual features: basophilic differentiation and a three-way translocation involving chromosomes 12, 15 and 17. In the few cases reported, basophilic differentiation was associated with a poor prognosis. In contrast, our patient responded promptly to the standard treatment with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) and obtained complete remission. To our knowledge, this is the first report of basophilic acute promyelocytic leukemia with the three-way translocation t(12;17;15) (p13; q24;q21).
摘要：
急性早幼粒细胞白血病是一种罕见的急性髓性白血病，其中未成熟的早幼粒细胞在骨髓中异常增殖。在大多数情况下,该疾病的特征是易位t(15;17)(q24;q21)，这导致了PML::RARA的形成，负责阻断骨髓分化和生存优势的致癌融合蛋白。这里,我们介绍了一例急性早幼粒细胞白血病，具有两个不寻常的特征：嗜碱性细胞分化和涉及染色体12、15和17的三向易位。在报告的少数案例中，嗜碱性细胞分化与不良预后相关。相比之下,我们的患者对全反式维甲酸(ATRA)和三氧化二砷(ATO)的标准治疗反应迅速,并获得完全缓解.据我们所知,这是三向易位t（12;17;15）（p13;q24;q21）的嗜碱性急性早幼粒细胞白血病的首次报道。
