%0 Case Reports
%T Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation.
%A Frazzetto S
%A Gullo L
%A Sapuppo G
%A Fazio M
%A Lo Faro C
%A Giunta G
%A Caravotta I
%A Mauro E
%A Parisi MS
%A Triolo AM
%A Parrinello NL
%A Consoli ML
%A També L
%A Cambria D
%A Marino S
%A Scuderi G
%A Di Raimondo F
%J Hematol Rep
%V 16
%N 2
%D 2024 Jun 12
%M 38921185
暂无%R 10.3390/hematolrep16020037
%X Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the formation of PML::RARA, an oncogenic fusion protein responsible for blocking myeloid differentiation and survival advantage. Here, we present a case of acute promyelocytic leukemia with two unusual features: basophilic differentiation and a three-way translocation involving chromosomes 12, 15 and 17. In the few cases reported, basophilic differentiation was associated with a poor prognosis. In contrast, our patient responded promptly to the standard treatment with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) and obtained complete remission. To our knowledge, this is the first report of basophilic acute promyelocytic leukemia with the three-way translocation t(12;17;15) (p13; q24;q21).