{Reference Type}: Case Reports
{Title}: Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation.
{Author}: Frazzetto S;Gullo L;Sapuppo G;Fazio M;Lo Faro C;Giunta G;Caravotta I;Mauro E;Parisi MS;Triolo AM;Parrinello NL;Consoli ML;També L;Cambria D;Marino S;Scuderi G;Di Raimondo F;
{Journal}: Hematol Rep
{Volume}: 16
{Issue}: 2
{Year}: 2024 Jun 12
暂无{DOI}: 10.3390/hematolrep16020037
{Abstract}: Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the formation of PML::RARA, an oncogenic fusion protein responsible for blocking myeloid differentiation and survival advantage. Here, we present a case of acute promyelocytic leukemia with two unusual features: basophilic differentiation and a three-way translocation involving chromosomes 12, 15 and 17. In the few cases reported, basophilic differentiation was associated with a poor prognosis. In contrast, our patient responded promptly to the standard treatment with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) and obtained complete remission. To our knowledge, this is the first report of basophilic acute promyelocytic leukemia with the three-way translocation t(12;17;15) (p13; q24;q21).