PDF(Pubmed)
Abstract：
UNASSIGNED: The Oxidative Balance Score (OBS), which quantifies the balance between antioxidants and pro-oxidants influenced by diet and lifestyle, is crucial given oxidative stress\'s significant role in Chronic Kidney Disease (CKD). This study aims to determine the association between OBS and CKD using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018.
UNASSIGNED: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018. OBS was constructed from a detailed array of 20 factors, including dietary nutrients and lifestyle behaviors. The relationship between OBS and CKD risk was evaluated using weighted logistic regression models, adjusted for potential confounders, with a generalized additive model (GAM) examining non-linear associations. Subgroup analyses and interaction effects across diverse demographic and clinical groups, along with sensitivity analyses, were performed to validate the findings.
UNASSIGNED: Among 32,120 participants analyzed, 4,786 were identified with CKD. Fully adjusted weighted logistic regression analysis revealed that each unit increase in OBS was associated with a 2% reduction in CKD prevalence [OR: 0.98 (0.98-0.99), P < 0.001]. Higher OBS quartiles were significantly correlated with a decreased CKD risk [Q4 vs. Q1: OR: 0.82 (0.68-0.98), P = 0.03; P for trend = 0.01]. The GAM and smoothed curve fit indicated a linear relationship between OBS and the risk of CKD. Stratified and sensitivity analyses further substantiated the inverse relationship between OBS and CKD prevalence.
UNASSIGNED: Our findings from the NHANES data affirm a significant inverse association between OBS and CKD risk in the U.S. population, underscoring the role of optimizing dietary and lifestyle factors in managing CKD risk. These results advocate for incorporating OBS considerations into CKD prevention and treatment strategies.
UNASSIGNED: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018. OBS was constructed from a detailed array of 20 factors, including dietary nutrients and lifestyle behaviors. The relationship between OBS and CKD risk was evaluated using weighted logistic regression models, adjusted for potential confounders, with a generalized additive model (GAM) examining non-linear associations. Subgroup analyses and interaction effects across diverse demographic and clinical groups, along with sensitivity analyses, were performed to validate the findings.
UNASSIGNED: Among 32,120 participants analyzed, 4,786 were identified with CKD. Fully adjusted weighted logistic regression analysis revealed that each unit increase in OBS was associated with a 2% reduction in CKD prevalence [OR: 0.98 (0.98-0.99), P < 0.001]. Higher OBS quartiles were significantly correlated with a decreased CKD risk [Q4 vs. Q1: OR: 0.82 (0.68-0.98), P = 0.03; P for trend = 0.01]. The GAM and smoothed curve fit indicated a linear relationship between OBS and the risk of CKD. Stratified and sensitivity analyses further substantiated the inverse relationship between OBS and CKD prevalence.
UNASSIGNED: Our findings from the NHANES data affirm a significant inverse association between OBS and CKD risk in the U.S. population, underscoring the role of optimizing dietary and lifestyle factors in managing CKD risk. These results advocate for incorporating OBS considerations into CKD prevention and treatment strategies.
摘要：
■氧化平衡评分（OBS），量化了受饮食和生活方式影响的抗氧化剂和促氧化剂之间的平衡，考虑到氧化应激在慢性肾脏病（CKD）中的重要作用，是至关重要的。本研究旨在使用1999-2018年国家健康与营养调查（NHANES）的数据确定OBS与CKD之间的关联。
■我们分析了1999年至2018年国家健康与营养检查调查（NHANES）的数据。OBS由20个因素的详细组成，包括饮食营养和生活方式行为。采用加权logistic回归模型评价OBS与CKD风险的关系,针对潜在的混杂因素进行了调整，用广义加性模型(GAM)检查非线性关联。亚组分析和跨不同人口统计学和临床组的相互作用效应，连同敏感性分析，进行了验证结果。
■在32,120名参与者中进行了分析，4,786例被鉴定为CKD。全调整加权logistic回归分析显示，OBS每增加一个单位与CKD患病率降低2%相关[OR：0.98(0.98-0.99)，P<0.001]。较高的OBS四分位数与CKD风险降低显着相关[Q4与Q1：或：0.82（0.68-0.98），P=0.03；趋势P=0.01]。GAM和平滑曲线拟合表明OBS与CKD风险之间存在线性关系。分层和敏感性分析进一步证实了OBS与CKD患病率之间的负相关关系。
■我们从NHANES数据中得出的结论证实了美国人群中OBS与CKD风险之间的显著负相关，强调优化饮食和生活方式因素在控制CKD风险中的作用。这些结果主张将OBS考虑纳入CKD预防和治疗策略。
■我们分析了1999年至2018年国家健康与营养检查调查（NHANES）的数据。OBS由20个因素的详细组成，包括饮食营养和生活方式行为。采用加权logistic回归模型评价OBS与CKD风险的关系,针对潜在的混杂因素进行了调整，用广义加性模型(GAM)检查非线性关联。亚组分析和跨不同人口统计学和临床组的相互作用效应，连同敏感性分析，进行了验证结果。
■在32,120名参与者中进行了分析，4,786例被鉴定为CKD。全调整加权logistic回归分析显示，OBS每增加一个单位与CKD患病率降低2%相关[OR：0.98(0.98-0.99)，P<0.001]。较高的OBS四分位数与CKD风险降低显着相关[Q4与Q1：或：0.82（0.68-0.98），P=0.03；趋势P=0.01]。GAM和平滑曲线拟合表明OBS与CKD风险之间存在线性关系。分层和敏感性分析进一步证实了OBS与CKD患病率之间的负相关关系。
■我们从NHANES数据中得出的结论证实了美国人群中OBS与CKD风险之间的显著负相关，强调优化饮食和生活方式因素在控制CKD风险中的作用。这些结果主张将OBS考虑纳入CKD预防和治疗策略。
