Abstract：
The aim of the study was to characterize retinal atrophy (RA) with progressive retinal atrophy symptoms in mixed breed dogs using ophthalmoscopy, spectral domain optical coherence tomography (SD-OCT) and electroretinography (ERG).The study was performed on 13 mixed breed dogs affected by retinal atrophy (11 males and 2 females that were 1.5-14 years old). Depending on the advancement of RA, SD-OCT examinations identified retinal abnormalities ranging from layer disorganisation to advanced atrophy. The most advanced RA occurred ventral to the optic disc. Total retinal thickness in both eyes (mean ± SD) was lower in dogs with RA compared to controls dorsally (77.7 ± 39.5 μm vs 173.5 ± 13.3 μm), ventrally (33.4 ± 29.9 μm vs 139.5 ± 10.8 μm), nasally (65.0 ± 34.5 μm vs 163.9 ± 11.0 μm) and temporally (61.8 ± 41.7 μm vs 171.9 ± 11.1 μm) to the optic disc. In dogs with locally normal architecture of inner retina, loss of definition of outer retinal layers occurred in many regions. Dark and light-adapted ERGs were reduced in 2 dogs with RA and were unrecordable in 11 dogs. Lesions evident in SD-OCT scans of mixed breed dogs affected with retinal atrophy initially appear ventrally to the optic disc and ventro-dorsally in advanced RA. In all mixed breed dogs with retinal atrophy, clinical signs and SD-OCT results correlate with ERG findings.
摘要：
该研究的目的是使用检眼镜检查来表征混种犬中具有进行性视网膜萎缩症状的视网膜萎缩（RA），谱域光学相干断层扫描（SD-OCT）和视网膜电图（ERG）。该研究是在13只受视网膜萎缩影响的混合品种狗（11只雄性和2只雌性，年龄为1.5-14岁）上进行的。根据RA的进步，SD-OCT检查确定了视网膜异常，从层紊乱到晚期萎缩。最先进的RA发生在视盘腹侧。与背侧对照组相比，RA犬的双眼视网膜总厚度（平均值±SD）较低（77.7±39.5μmvs173.5±13.3μm），腹侧（33.4±29.9μmvs139.5±10.8μm），鼻侧（65.0±34.5μmvs163.9±11.0μm）和时间上（61.8±41.7μmvs171.9±11.1μm）到视盘。在内部视网膜局部正常结构的狗中，在许多区域发生了视网膜外层的定义丧失。在2只患有RA的狗中，黑暗和光照适应的ERG减少，而在11只狗中无法记录。受视网膜萎缩影响的混合品种犬的SD-OCT扫描中明显的病变最初出现在视盘的腹侧和晚期RA的腹侧。在所有有视网膜萎缩的混种狗中，临床体征和SD-OCT结果与ERG结果相关.
