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Abstract：
OBJECTIVE: To evaluate the intraoperative central corneal epithelial thickness (ET) as measured by optical coherence pachymetry (OCP) in myopic eyes undergoing alcohol-assisted photorefractive keratectomy (PRK).
METHODS: A retrospective review of patients who underwent alcohol-assisted PRK was performed. Data were abstracted on age, gender, contact lens (CL) wear, preoperative refractive errors, keratometry, topographic and ultrasonic pachymetry, and intraoperative OCP measurements before and after epithelium removal. The central ET was calculated by subtracting OCP measurement after epithelium removal from the OCP measurement prior to epithelium removal.
RESULTS: The study comprised of 162 consecutive eyes from 81 patients. Mean age was 26.73 ± 6.47 years, 50.6% were males. CL was used in 92 eyes (56.8%). The mean sphere and spherical equivalent were -3.60 ± 1.84 D and -3.26 ± 1.85D, respectively. The mean intraoperative ET was 58.22 ± 17.53 µm (range, 15-121µm). Fifty-five percent of the eyes had an ET measurement above or below the range of 40-60µm. ET was significantly higher in the second operated eye compared to the first operated eye (p = 0.006), and an association was found to CL-wear (p = 0.03). There was no significant difference in thickness between genders (p = 0.62), and no correlation to patient age (p = 0.45, rp = 0.06), refractive errors (p > 0.30,rp=-0.07-0.08), nor keratometry(p > 0.80, rp=-0.01- (-0.02)).
CONCLUSIONS: The intraoperative assessment of ET in alcohol-assisted PRK showed a high variability of the central corneal epithelium, with a significant difference between the first and second operated eyes. This difference may have implications when the epithelium is not included in the surgical planning in surface ablation.
METHODS: A retrospective review of patients who underwent alcohol-assisted PRK was performed. Data were abstracted on age, gender, contact lens (CL) wear, preoperative refractive errors, keratometry, topographic and ultrasonic pachymetry, and intraoperative OCP measurements before and after epithelium removal. The central ET was calculated by subtracting OCP measurement after epithelium removal from the OCP measurement prior to epithelium removal.
RESULTS: The study comprised of 162 consecutive eyes from 81 patients. Mean age was 26.73 ± 6.47 years, 50.6% were males. CL was used in 92 eyes (56.8%). The mean sphere and spherical equivalent were -3.60 ± 1.84 D and -3.26 ± 1.85D, respectively. The mean intraoperative ET was 58.22 ± 17.53 µm (range, 15-121µm). Fifty-five percent of the eyes had an ET measurement above or below the range of 40-60µm. ET was significantly higher in the second operated eye compared to the first operated eye (p = 0.006), and an association was found to CL-wear (p = 0.03). There was no significant difference in thickness between genders (p = 0.62), and no correlation to patient age (p = 0.45, rp = 0.06), refractive errors (p > 0.30,rp=-0.07-0.08), nor keratometry(p > 0.80, rp=-0.01- (-0.02)).
CONCLUSIONS: The intraoperative assessment of ET in alcohol-assisted PRK showed a high variability of the central corneal epithelium, with a significant difference between the first and second operated eyes. This difference may have implications when the epithelium is not included in the surgical planning in surface ablation.
摘要：
目的：通过光学相干测厚法（OCP）测量的近视患者行酒精辅助屈光性角膜切削术（PRK）术中中央角膜上皮厚度（ET）。
方法：对接受酒精辅助PRK的患者进行回顾性分析。数据是关于年龄的抽象，性别,隐形眼镜(CL)磨损,术前屈光不正,角膜曲率测量,地形和超声波测厚仪，术中OCP测量前和后上皮去除。通过从上皮去除之前的OCP测量中减去上皮去除之后的OCP测量来计算中心ET。
结果：该研究包括来自81名患者的162只连续眼睛。平均年龄为26.73±6.47岁，50.6%为男性。92眼使用CL（56.8%）。平均球面和球面当量分别为-3.60±1.84D和-3.26±1.85D，分别。术中平均ET为58.22±17.53µm（范围，15-121µm）。55％的眼睛的ET测量值高于或低于40-60µm的范围。与第一眼相比，第二眼的ET明显更高（p=0.006），发现与CL磨损有关联（p=0.03）。性别之间的厚度没有显着差异（p=0.62），与患者年龄无关(p=0.45，rp=0.06)，屈光不正（p>0.30，rp=-0.07-0.08），角膜曲率测量（p>0.80，rp=-0.01-（-0.02））。
结论：术中评估酒精辅助PRK的ET显示中央角膜上皮的高度变异性，第一眼和第二眼之间有显著差异。当上皮不包括在表面消融的手术计划中时，这种差异可能会产生影响。
方法：对接受酒精辅助PRK的患者进行回顾性分析。数据是关于年龄的抽象，性别,隐形眼镜(CL)磨损,术前屈光不正,角膜曲率测量,地形和超声波测厚仪，术中OCP测量前和后上皮去除。通过从上皮去除之前的OCP测量中减去上皮去除之后的OCP测量来计算中心ET。
结果：该研究包括来自81名患者的162只连续眼睛。平均年龄为26.73±6.47岁，50.6%为男性。92眼使用CL（56.8%）。平均球面和球面当量分别为-3.60±1.84D和-3.26±1.85D，分别。术中平均ET为58.22±17.53µm（范围，15-121µm）。55％的眼睛的ET测量值高于或低于40-60µm的范围。与第一眼相比，第二眼的ET明显更高（p=0.006），发现与CL磨损有关联（p=0.03）。性别之间的厚度没有显着差异（p=0.62），与患者年龄无关(p=0.45，rp=0.06)，屈光不正（p>0.30，rp=-0.07-0.08），角膜曲率测量（p>0.80，rp=-0.01-（-0.02））。
结论：术中评估酒精辅助PRK的ET显示中央角膜上皮的高度变异性，第一眼和第二眼之间有显著差异。当上皮不包括在表面消融的手术计划中时，这种差异可能会产生影响。
