Abstract：
Intestinal dilatation syndrome (IDS) is a segmental enteropathy characterized by dilatation of the junction of the ileum and jejunum (Meckel\'s diverticulum). IDS severely affects the poultry industry by causing a chronic and irreversible drop in egg laying, reducing feed conversion efficiency, and increasing the mortality rate. The clinical and pathological features of IDS in white laying hens were described, and viral molecular and metagenomic research was conducted. The 50- to 60-day-old chickens presented pale mucosa, apathy, depression, ruffled feathers, and diarrhoea, accompanied by a 20% loss in fertile egg production, 20% culling of birds, and 5% mortality. The main findings at necropsy were marked intestinal dilatation with intestinal stasis, a narrow distal jejunum in the region of Meckel\'s diverticulum, and undigested food. Microscopic analysis revealed marked atrophic lymphoplasmacytic and heterophilic enteritis with hyperplastic crypts, ulceration, and heterophilic and lymphoplasmacytic perineuritis. The molecular assays consistently detected the presence of chicken parvovirus in the three segments of the intestine, pancreas, and proventriculus, as well as chicken megrivirus in the intestinal contents. Marked atrophic enteritis with perineuritis and intestinal stasis are associated with clinical manifestations of poor intestinal absorption and secondary bacterial infection. Our data provide useful information about IDS and highlight the importance of further studies to determine the specific role of each detected virus in this syndrome.RESEARCH HIGHLIGHTS IDS presented pathognomonic dilatation of the jejunum up to Meckel\'s diverticulum.IDS caused weight loss, decreased egg production, and increased culling and mortality.Chicken parvovirus (ChPV) was consistently detected through PCR assays.Chicken megrivirus (ChMV) was consistently detected through viral metagenomics.
摘要：
肠扩张综合征（IDS）是一种节段性肠病，其特征是回肠和空肠（Meckel憩室）的交界处扩张。IDS严重影响家禽业，导致产卵的慢性和不可逆转的下降，降低饲料转化效率，增加死亡率。描述了白蛋鸡IDS的临床和病理特征，并进行了病毒分子和宏基因组研究。50至60天大的鸡粘膜苍白，冷漠,抑郁症,荷叶边的羽毛,腹泻,伴随着产卵损失20%，20%的鸟类扑杀，和5%的死亡率。尸检的主要发现是明显的肠道扩张伴肠道淤滞，Meckel憩室区域的狭窄远端空肠，和未消化的食物。显微镜分析显示明显的萎缩性淋巴浆细胞性和嗜异性肠炎伴增生隐窝，溃疡,和嗜异性和淋巴浆细胞性神经周炎。分子分析一致地检测到鸡细小病毒在肠道的三个部分的存在，胰腺,和proventricuus，以及鸡的肠道内容物中的大疱病毒。伴有神经周炎和肠淤滞的萎缩性肠炎与肠吸收不良和继发细菌感染的临床表现有关。我们的数据提供了有关IDS的有用信息，并强调了进一步研究以确定每种检测到的病毒在该综合征中的特定作用的重要性。研究重点IDS呈现空肠直至Meckel憩室的病理性扩张。IDS导致体重减轻，鸡蛋产量下降，以及增加扑杀和死亡率。通过PCR测定一致地检测鸡细小病毒(ChPV)。通过病毒宏基因组学始终检测到鸡大疱疹病毒（ChMV）。
