PDF(Pubmed)
Abstract：
OBJECTIVE: To investigate the association between cumulative exposure to low-density lipoprotein cholesterol (LDL-C) and carotid intima-media thickness (IMT) in the young adulthood population.
METHODS: Young adult subject (18-45 year old) from the Kailuan Study group who participated in the same period of follow-up and received carotid artery ultrasound were selected as the observation subjects. Among them, 3651 cases met the inclusion criteria, which required that carotid artery color ultrasound examinations be completed from 2010 to 2016, with complete IMT measurements, LDL-C data collected at least twice before carotid ultrasound, and participants\' age to be ≤ 45 years at the time of carotid artery color ultrasound examination. Linear regression was used to analyze the correlation between time-weighted average (TWA) to LDL-C cumulative exposure and IMT the young population. Logistic regression was used to analyze the effects of different TWA groups on IMT thickening. Considering that the use of anti hypertensive drugs and lipid-lowering drugs may affect TWA LDL-C, this study excluded people taking antihypertensive drugs and lipid-lowering drugs, and conducted a repeat analysis of the main results.
RESULTS: There was a positive correlation between TWA LDL-C and IMT, with IMT increasing by 0.017 mm when TWA LDL-C increased by 1 mmol/L * year. The TWA LDL-C in the highest group was identified as a risk factor for IMT thickening, with odds ratio (OR) values of 1.812(1.027 ~ 3.200) in the T3 group. After excluding patients taking antihypertensive drugs and lipid-lowering drugs, the results still showed that the T3 group with the highest TWA LDL-C was a risk factor for IMT thickening, with an OR value of 1.850(0.988-3.464), P for trend is 0.043.
CONCLUSIONS: This cohort study revealed that TWA LDL-C is positively correlated with IMT in young adulthood for risk stratification, and control LDL-C levels at an earlier age may reduce the lifetime risk of developing atherosclerotic disease.
BACKGROUND: ChiCTR-TNC-11001489.
METHODS: Young adult subject (18-45 year old) from the Kailuan Study group who participated in the same period of follow-up and received carotid artery ultrasound were selected as the observation subjects. Among them, 3651 cases met the inclusion criteria, which required that carotid artery color ultrasound examinations be completed from 2010 to 2016, with complete IMT measurements, LDL-C data collected at least twice before carotid ultrasound, and participants\' age to be ≤ 45 years at the time of carotid artery color ultrasound examination. Linear regression was used to analyze the correlation between time-weighted average (TWA) to LDL-C cumulative exposure and IMT the young population. Logistic regression was used to analyze the effects of different TWA groups on IMT thickening. Considering that the use of anti hypertensive drugs and lipid-lowering drugs may affect TWA LDL-C, this study excluded people taking antihypertensive drugs and lipid-lowering drugs, and conducted a repeat analysis of the main results.
RESULTS: There was a positive correlation between TWA LDL-C and IMT, with IMT increasing by 0.017 mm when TWA LDL-C increased by 1 mmol/L * year. The TWA LDL-C in the highest group was identified as a risk factor for IMT thickening, with odds ratio (OR) values of 1.812(1.027 ~ 3.200) in the T3 group. After excluding patients taking antihypertensive drugs and lipid-lowering drugs, the results still showed that the T3 group with the highest TWA LDL-C was a risk factor for IMT thickening, with an OR value of 1.850(0.988-3.464), P for trend is 0.043.
CONCLUSIONS: This cohort study revealed that TWA LDL-C is positively correlated with IMT in young adulthood for risk stratification, and control LDL-C levels at an earlier age may reduce the lifetime risk of developing atherosclerotic disease.
BACKGROUND: ChiCTR-TNC-11001489.
摘要：
目的：探讨青年人群低密度脂蛋白胆固醇（LDL-C）累积暴露与颈动脉内膜中层厚度（IMT）的关系。
方法：选取同期参加随访并接受颈动脉超声检查的开兰研究组年轻（18～45岁）受试者作为观察对象。其中,3651例符合纳入标准，要求从2010年到2016年完成颈动脉彩色超声检查，并完成IMT测量，在颈动脉超声检查前至少收集两次LDL-C数据，和参与者年龄≤45岁时的颈动脉彩色超声检查。采用线性回归分析年轻人群时间加权平均(TWA)至LDL-C累积暴露量与IMT的相关性。采用Logistic回归分析不同TWA组对IMT增厚的影响。考虑到使用抗高血压药物和降脂药可能会影响TWALDL-C，这项研究排除了服用降压药和降脂药的人，并对主要结果进行了重复分析。
结果：TWALDL-C与IMT呈正相关，当TWALDL-C增加1mmol/L*年时，IMT增加0.017mm。最高组的TWALDL-C被确定为IMT增厚的危险因素，T3组比值比(OR)值为1.812(1.027~3.200)。排除服用降压药和降脂药的患者后,结果仍然显示，TWALDL-C最高的T3组是IMT增厚的危险因素，OR值为1.850(0.988-3.464)，趋势的P为0.043。
结论：这项队列研究表明，TWALDL-C与年轻成年期的IMT呈正相关，在较早的年龄控制LDL-C水平可能会降低患动脉粥样硬化疾病的终生风险。
背景：ChiCTR-TNC-11001489。
方法：选取同期参加随访并接受颈动脉超声检查的开兰研究组年轻（18～45岁）受试者作为观察对象。其中,3651例符合纳入标准，要求从2010年到2016年完成颈动脉彩色超声检查，并完成IMT测量，在颈动脉超声检查前至少收集两次LDL-C数据，和参与者年龄≤45岁时的颈动脉彩色超声检查。采用线性回归分析年轻人群时间加权平均(TWA)至LDL-C累积暴露量与IMT的相关性。采用Logistic回归分析不同TWA组对IMT增厚的影响。考虑到使用抗高血压药物和降脂药可能会影响TWALDL-C，这项研究排除了服用降压药和降脂药的人，并对主要结果进行了重复分析。
结果：TWALDL-C与IMT呈正相关，当TWALDL-C增加1mmol/L*年时，IMT增加0.017mm。最高组的TWALDL-C被确定为IMT增厚的危险因素，T3组比值比(OR)值为1.812(1.027~3.200)。排除服用降压药和降脂药的患者后,结果仍然显示，TWALDL-C最高的T3组是IMT增厚的危险因素，OR值为1.850(0.988-3.464)，趋势的P为0.043。
结论：这项队列研究表明，TWALDL-C与年轻成年期的IMT呈正相关，在较早的年龄控制LDL-C水平可能会降低患动脉粥样硬化疾病的终生风险。
背景：ChiCTR-TNC-11001489。
