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Abstract：
BACKGROUND: Cardiovascular diseases are leading causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Cardiac involvement in SLE can often go undetected. Three-dimensional (3D) speckle tracking echocardiography (STE) is a noninvasive imaging technique that can assess the function of the heart\'s ventricles in an accurate and reproducible way. This makes it an attractive option for detecting early signs of heart disease in SLE patients. By identifying these subclinical cardiac abnormalities, 3D-STE may help reduce the negative impact of cardiovascular diseases in SLE population. Therefore, this study aimed to compare the left ventricular (LV) function between patients with SLE compared to age- and gender-matched controls using two-dimensional (2D) and 3D-STE.
RESULTS: The current study found no significant differences in left ventricle ejection fraction, left ventricle end-diastolic volume, left ventricle end-systolic volume, left ventricle end-diastolic mass, and left ventricle end-systolic mass between the two groups. However, the SLE group exhibited a significantly lower LV global longitudinal strain (GLS) compared to the control group according to all types of echocardiographic assessments, including 3D and 2D long-axis strain, apical 2-chamber, and apical 4-chamber assessments (all P values < 0.05). Furthermore, a good inter-rater reliability and intra-rater reliability were observed regarding the LVGLS measurement with 3D-STE. Additionally, the study identified a significant correlation between LVGLS and SLE duration (r (50) = 0.46, P < 0.001). The use of prednisolone and nephrology disorders was also found to impact LVGLS measurements.
CONCLUSIONS: Despite a normal LVEF in patients with SLE, LVGLS measurements indicated that LV systolic dysfunction was observed more frequently in SLE patients compared to their healthy counterparts. Therefore, advanced 3D-STE techniques may be useful in identifying subtle abnormalities in LV function in SLE patients.
RESULTS: The current study found no significant differences in left ventricle ejection fraction, left ventricle end-diastolic volume, left ventricle end-systolic volume, left ventricle end-diastolic mass, and left ventricle end-systolic mass between the two groups. However, the SLE group exhibited a significantly lower LV global longitudinal strain (GLS) compared to the control group according to all types of echocardiographic assessments, including 3D and 2D long-axis strain, apical 2-chamber, and apical 4-chamber assessments (all P values < 0.05). Furthermore, a good inter-rater reliability and intra-rater reliability were observed regarding the LVGLS measurement with 3D-STE. Additionally, the study identified a significant correlation between LVGLS and SLE duration (r (50) = 0.46, P < 0.001). The use of prednisolone and nephrology disorders was also found to impact LVGLS measurements.
CONCLUSIONS: Despite a normal LVEF in patients with SLE, LVGLS measurements indicated that LV systolic dysfunction was observed more frequently in SLE patients compared to their healthy counterparts. Therefore, advanced 3D-STE techniques may be useful in identifying subtle abnormalities in LV function in SLE patients.
摘要：
背景：心血管疾病是系统性红斑狼疮（SLE）患者发病和死亡的主要原因。SLE的心脏受累通常未被发现。三维（3D）斑点追踪超声心动图（STE）是一种无创成像技术，可以以准确且可重复的方式评估心脏心室的功能。这使其成为检测SLE患者心脏病早期体征的有吸引力的选择。通过识别这些亚临床心脏异常，3D-STE可能有助于减少SLE人群中心血管疾病的负面影响。因此,本研究旨在使用二维(2D)和3D-STE比较SLE患者与年龄和性别匹配的对照组之间的左心室(LV)功能.
结果：当前研究发现左心室射血分数没有显着差异，左心室舒张末期容积,左心室收缩末期容积,左心室舒张末期肿块,两组之间的左心室收缩末期质量。然而,根据所有类型的超声心动图评估，与对照组相比，SLE组的LV整体纵向应变（GLS）均显着降低。包括3D和2D长轴应变，顶端2腔，和心尖4室评估（所有P值<0.05）。此外，关于使用3D-STE进行LVGLS测量，观察到了良好的评分者间可靠性和评分者间可靠性。此外,研究发现LVGLS与SLE病程之间存在显著相关性(r(50)=0.46,P<0.001).还发现使用泼尼松龙和肾病疾病会影响LVGLS测量。
结论：尽管SLE患者的LVEF正常，LVGLS测量表明，与健康者相比，在SLE患者中更频繁地观察到LV收缩功能障碍。因此,先进的3D-STE技术可能有助于识别SLE患者LV功能的细微异常.
结果：当前研究发现左心室射血分数没有显着差异，左心室舒张末期容积,左心室收缩末期容积,左心室舒张末期肿块,两组之间的左心室收缩末期质量。然而,根据所有类型的超声心动图评估，与对照组相比，SLE组的LV整体纵向应变（GLS）均显着降低。包括3D和2D长轴应变，顶端2腔，和心尖4室评估（所有P值<0.05）。此外，关于使用3D-STE进行LVGLS测量，观察到了良好的评分者间可靠性和评分者间可靠性。此外,研究发现LVGLS与SLE病程之间存在显著相关性(r(50)=0.46,P<0.001).还发现使用泼尼松龙和肾病疾病会影响LVGLS测量。
结论：尽管SLE患者的LVEF正常，LVGLS测量表明，与健康者相比，在SLE患者中更频繁地观察到LV收缩功能障碍。因此,先进的3D-STE技术可能有助于识别SLE患者LV功能的细微异常.
