Abstract：
Many strategies for regenerating the damaged tissues or degenerating cells are employed in regenerative medicine. Stem cell technology is a modern strategy of the recent approaches, particularly the use of mesenchymal stem cells (MCSs). The ability of MSCs to differentiate as well as their characteristic behaviour as paracrine effector has established them as key elements in tissue repair (Shaer et al., 20141). Recently, extracellular vesicles (EVs) shed by MSCs have emerged as a promising cell free therapy (Citation}Rani, S., Ryan, A. E., Griffin, M. D., and Ritter, T., 20152). This comprehensive review encompasses MSCs-derived exosomes and their therapeutic potential as nanotherapeutics. We also discuss their potency as drug delivery nano-carriers in comparison with liposomes. A better knowledge of EVs behaviour in vivo and of their mechanism of action are key to determine parameters of an optimal formulation in pilot studies and to establish industrial processes.
摘要：
再生医学中采用了许多用于再生受损组织或退化细胞的策略。干细胞技术是最近方法的现代策略，特别是使用间充质干细胞（MCSs）。MSC的分化能力以及它们作为旁分泌效应物的特征性行为已将它们确立为组织修复中的关键要素（Shaer等人。,20141).最近,由MSCs脱落的细胞外囊泡（EV）已成为一种有前途的无细胞疗法（引用}Rani，S、Ryan,A.E.,格里芬,M.D.,还有Ritter,T.,20152).这篇全面的综述涵盖了MSC衍生的外泌体及其作为纳米治疗剂的治疗潜力。我们还讨论了它们与脂质体相比作为药物递送纳米载体的效力。更好地了解电动汽车在体内的行为及其作用机制是确定试点研究中最佳配方参数和建立工业过程的关键。
