Abstract：
OBJECTIVE: To evaluate the predictive factors of neovascular age-related macular degeneration (nAMD) with poor response to three loading doses of intravitreal bevacizumab (IVB).
METHODS: A retrospective cohort study was performed on nAMD patients three loading IVB initial treatment. The patients were divided into two groups, without residual fluid on optical coherence tomography (OCT) images (Group 1) and with residual fluid (Group 2). Demographic data, OCT findings, and morphological features of macular neovascularization (MNV) in optical coherence tomography angiography (OCTA) were recorded.
RESULTS: The study included one hundred thirty-six eyes of 120 patients (Group 1: n = 66 eyes, Group 2: n = 70 eyes). Central macular thickness, presence of intraretinal fluid, subretinal fluid, hyperreflective foci-band, pigment epithelial detachment (PED), and prechoroidal cleft were similar between the two groups. Pre-injection central choroidal thickness (CCT) was 214.17 ± 50.28 µm in Group 1 and 247.40 ± 60.55 µm in Group 2 (p = 0.021). PED width (p = 0.028) and PED area (p = 0.042) were statistically significantly higher in Group 1. When the morphology of MNV in OCTA was examined, branching (p = 0.736), loops (p = 0.442), peripheral arcade (p = 0.600), hypointense halo (p = 0.779), sea fan (p = 0.250), medusa (p = 0.255), pruned vascular tree pattern (p = 0.148), capillary fringe (p = 0.683) were similar in both groups. The presence of a closed circuit pattern was significantly higher in Group 2 (p = 0.028).
CONCLUSIONS: Initial CCT and closed circuit pattern MNV were higher in IVB-resistant cases. It was observed that PEDs with large bases and areas responded significantly better to loading therapy. The presence of a closed-circuit pattern was an independent risk factor for poor response to loading therapy. Retrospectively registered.
BACKGROUND: 2011-KAEK-25 2023/05-08.
METHODS: A retrospective cohort study was performed on nAMD patients three loading IVB initial treatment. The patients were divided into two groups, without residual fluid on optical coherence tomography (OCT) images (Group 1) and with residual fluid (Group 2). Demographic data, OCT findings, and morphological features of macular neovascularization (MNV) in optical coherence tomography angiography (OCTA) were recorded.
RESULTS: The study included one hundred thirty-six eyes of 120 patients (Group 1: n = 66 eyes, Group 2: n = 70 eyes). Central macular thickness, presence of intraretinal fluid, subretinal fluid, hyperreflective foci-band, pigment epithelial detachment (PED), and prechoroidal cleft were similar between the two groups. Pre-injection central choroidal thickness (CCT) was 214.17 ± 50.28 µm in Group 1 and 247.40 ± 60.55 µm in Group 2 (p = 0.021). PED width (p = 0.028) and PED area (p = 0.042) were statistically significantly higher in Group 1. When the morphology of MNV in OCTA was examined, branching (p = 0.736), loops (p = 0.442), peripheral arcade (p = 0.600), hypointense halo (p = 0.779), sea fan (p = 0.250), medusa (p = 0.255), pruned vascular tree pattern (p = 0.148), capillary fringe (p = 0.683) were similar in both groups. The presence of a closed circuit pattern was significantly higher in Group 2 (p = 0.028).
CONCLUSIONS: Initial CCT and closed circuit pattern MNV were higher in IVB-resistant cases. It was observed that PEDs with large bases and areas responded significantly better to loading therapy. The presence of a closed-circuit pattern was an independent risk factor for poor response to loading therapy. Retrospectively registered.
BACKGROUND: 2011-KAEK-25 2023/05-08.
摘要：
目的：评估对三种负载剂量的玻璃体内贝伐单抗（IVB）反应不佳的新生血管性年龄相关性黄斑变性（nAMD）的预测因素。
方法：对nAMD患者进行3次负荷IVB初始治疗的回顾性队列研究。将患者分为两组,光学相干断层扫描（OCT）图像上无残留液体（第1组）和有残留液体（第2组）。人口统计数据,OCT发现,并记录光学相干断层扫描血管造影（OCTA）中黄斑新生血管（MNV）的形态学特征。
结果：该研究包括120名患者的136只眼（第1组：n=66只眼，第2组：n=70只眼）。中央黄斑厚度，存在视网膜内液体，视网膜下液,超反射聚焦带，色素上皮脱离（PED），两组之间的脉络膜前裂隙相似。第1组预注射中央脉络膜厚度（CCT）为214.17±50.28µm，第2组为247.40±60.55µm（p=0.021）。第1组的PED宽度（p=0.028）和PED面积（p=0.042）在统计学上明显更高。当检查OCTA中MNV的形态时，分支(p=0.736)，循环（p=0.442），外围拱廊（p=0.600），低信号晕(p=0.779)，海扇(p=0.250)，美杜莎（p=0.255），修剪的血管树模式(p=0.148)，两组毛细血管边缘(p=0.683)相似.闭合电路图案的存在在第2组中显著更高(p=0.028)。
结论：在IVB耐药病例中，初始CCT和闭路模式MNV较高。观察到具有大碱基和面积的PED对负荷疗法的反应明显更好。闭路模式的存在是负荷治疗反应不佳的独立危险因素。追溯登记。
背景：2011-KAEK-252023/05-08。
方法：对nAMD患者进行3次负荷IVB初始治疗的回顾性队列研究。将患者分为两组,光学相干断层扫描（OCT）图像上无残留液体（第1组）和有残留液体（第2组）。人口统计数据,OCT发现,并记录光学相干断层扫描血管造影（OCTA）中黄斑新生血管（MNV）的形态学特征。
结果：该研究包括120名患者的136只眼（第1组：n=66只眼，第2组：n=70只眼）。中央黄斑厚度，存在视网膜内液体，视网膜下液,超反射聚焦带，色素上皮脱离（PED），两组之间的脉络膜前裂隙相似。第1组预注射中央脉络膜厚度（CCT）为214.17±50.28µm，第2组为247.40±60.55µm（p=0.021）。第1组的PED宽度（p=0.028）和PED面积（p=0.042）在统计学上明显更高。当检查OCTA中MNV的形态时，分支(p=0.736)，循环（p=0.442），外围拱廊（p=0.600），低信号晕(p=0.779)，海扇(p=0.250)，美杜莎（p=0.255），修剪的血管树模式(p=0.148)，两组毛细血管边缘(p=0.683)相似.闭合电路图案的存在在第2组中显著更高(p=0.028)。
结论：在IVB耐药病例中，初始CCT和闭路模式MNV较高。观察到具有大碱基和面积的PED对负荷疗法的反应明显更好。闭路模式的存在是负荷治疗反应不佳的独立危险因素。追溯登记。
背景：2011-KAEK-252023/05-08。
