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Abstract：
To use Optical Coherence Tomography (OCT) to measure scleral thickness (ST) and subfoveal choroid thickness (SFCT) in patients with Branch Retinal Vein Occlusion (BRVO) and to conduct a correlation analysis. A cross-sectional study was conducted. From May 2022 to December 2022, a total of 34 cases (68 eyes) of untreated unilateral Branch Retinal Vein Occlusion (BRVO) patients were recruited at the Affiliated Eye Hospital of Nanchang University. Among these cases, 31 were temporal branch vein occlusions, 2 were nasal branch occlusions, and 1 was a superior branch occlusion. Additionally, 39 cases (39 eyes) of gender- and age-matched control eyes were included in the study. Anterior Segment Optical Coherence Tomography (AS-OCT) was used to measure ST at 6 mm superior, inferior, nasal, and temporal to the limbus, while Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) was used to measure SFCT. The differences in ST and SFCT between the affected eye, contralateral eye, and control eye of BRVO patients were compared and analyzed for correlation. The axial lengths of the BRVO-affected eye, contralateral eye, and control group were (22.92 ± 0.30) mm, (22.89 ± 0.32) mm and (22.90 ± 0.28) mm respectively, with no significant difference in axial length between the affected eye and contralateral eye (P > 0.05). The SFCT and ST measurements in different areas showed significant differences between the BRVO-affected eye, contralateral eye in BRVO patients (P < 0.05). The CRT of BRVO-affected eyes was significantly higher than that of the contralateral eyes and the control eyes (P < 0.001). In comparison between BRVO-affected eyes and control eyes, there were no statistically significant differences in age and axial length between the two groups (P > 0.05). However, significant differences were observed in SFCT and temporal, nasal, superior, and inferior ST between the two groups (P < 0.05). The difference in temporal ST between the contralateral eyes and the control eyes was not statistically significant (t = - 0.35, P = 0.73). However, the contralateral group showed statistically significant increases in SFCT, nasal, superior and inferior ST compared to control eyes (t = - 3.153, 3.27, 4.21, 4.79, P = 0.002, 0.002, < 0.001, < 0.001). However, the difference between the CRT of the contralateral and control eyes was not statistically significant (P = 0.421). When comparing SFCT and ST between BRVO-affected eyes with and without macular edema, no statistically significant differences were found (t = - 1.10, 0.45, - 1.30, - 0.30, 1.00; P = 0.28, 0.66, 0.21, 0.77, 0.33). The thickness of SFCT and temporal ST in major BRVO group is higher than the macular BRVO group and the difference was statistically significant (t = 6.39, 7.17, P < 0.001 for all). Pearson correlation analysis revealed that in BRVO patients, there was a significant positive correlation between SFCT/CRT and temporal ST (r = 0.288, 0.355, P = 0.049, 0.04). However, there was no correlation between SFCT/CRT and nasal ST, superior ST, and inferior ST (P > 0.05). In BRVO patients, both SFCT/CRT and ST increase, and there is a significant correlation between SFCT/CRT and the ST at the site of vascular occlusion.
摘要：
应用光学相干断层扫描(OCT)测量视网膜分支静脉阻塞(BRVO)患者巩膜厚度(ST)和中心凹下脉络膜厚度(SFCT)，并进行相关性分析。进行了横断面研究。从2022年5月至2022年12月，在南昌大学附属眼科医院共招募34例（68眼）未经治疗的单侧视网膜分支静脉阻塞（BRVO）患者。在这些案例中,31例颞侧分支静脉闭塞，2个是鼻分支闭塞，1为上分支闭塞。此外,39例（39眼）性别和年龄匹配的对照眼纳入研究。前段光学相干断层扫描（AS-OCT）用于测量高6mm处的ST，劣等,鼻部,和暂时的边缘，而增强深度成像光学相干断层扫描（EDI-OCT）用于测量SFCT。受影响的眼睛之间的ST和SFCT的差异，对侧眼,对BRVO患者的对照眼进行比较和相关性分析。受BRVO影响的眼睛的轴向长度，对侧眼,对照组为(22.92±0.30)mm,(22.89±0.32)mm,(22.90±0.28)mm,患眼与对侧眼轴长无显著差异(P>0.05)。不同区域的SFCT和ST测量显示BRVO受累眼之间存在显着差异，BRVO患者对侧眼(P<0.05)。受BRVO影响的眼睛的CRT明显高于对侧眼睛和对照眼睛（P<0.001）。比较受BRVO影响的眼睛和对照眼睛，两组患者年龄和眼轴长度比较差异无统计学意义(P>0.05)。然而,在SFCT和时间上观察到显著差异，鼻部,上级,下位ST段的差异有统计学意义(P<0.05)。对侧眼与对照眼的时间ST差异无统计学意义（t=-0.35，P=0.73）。然而,对侧组SFCT有统计学意义的增加，鼻部,与对照组眼相比（t=-3.153、3.27、4.21、4.79，P=0.002、0.002，<0.001，<0.001）。然而,对侧和对照组的CRT差异无统计学意义（P=0.421）。当比较有和没有黄斑水肿的BRVO受累的眼睛之间的SFCT和ST时，差异无统计学意义(t=-1.10,0.45,-1.30,-0.30,1.00;P=0.28,0.66,0.21,0.77,0.33).主要BRVO组的SFCT和颞叶ST厚度高于黄斑BRVO组，差异有统计学意义（t=6.39、7.17，P均<0.001）。Pearson相关分析显示，在BRVO患者中，SFCT/CRT与颞叶ST呈正相关(r=0.288、0.355,P=0.049、0.04)。然而,SFCT/CRT与鼻ST无相关性,上级ST,下ST段(P>0.05)。在BRVO患者中，SFCT/CRT和ST均增加，SFCT/CRT与血管闭塞部位的ST有显著的相关性。
